一类线性Weingarten子流形的分类问题

主要研究了de Sitter空间中的线性Weingarten子流形,根据截面曲率对其进行分类.结果表明,这类子流形是全脐子流形或者是全脐子流形的乘积流形.     

草麻黄提取物对小菜蛾的生物活性研究

研究草麻黄提取产物对小菜蛾生物活性的影响.结果表明,当提取液处理浓度为500g/L时,氯仿、甲醇、乙醇、丙酮和石油醚的提取物可引起小菜蛾幼虫死亡,其死亡率分别为82%,64%,62%,48%,46%,且都随提取物浓度的降低而减小;5种溶剂的提取物对小菜蛾的卵都具有一定的毒杀作用,作用最强的为高浓度(500g/L)的氯仿提取物;卵的孵化率随提取物浓度的升高而显著降低,提取物对小菜蛾的初孵幼虫具有一定的杀死作用,当浓度为500g/L时,氯仿提取物可引起90%的小菜蛾初孵幼虫的死亡.     

中原经济区中心城市城区新型城镇化水平综合评价研究

结合中原经济区中心城市发展实际,总结出中原经济区中心城市城区新型城镇化综合评价的指标体系,包括二级指标6类,即城市人口与地域指标、城市经济指标、城市生活方式指标、城市发展潜力指标、城市基础设施指标、城市生态环境指标,三级指标21类.对指标体系进行主成分分析和Q聚类分析,对中原经济区中心城市城区新型城镇化水平做出对比,将中原经济区中心城市城区新型城镇化发展水平划分为4类,在此基础上对4类城市新型城镇化发展的特点进行归纳总结.     

超长双层网壳结构自振特性

对超长网壳结构同一面层的杆件进行不同数量的替换，通过结果的对比总结了替换数目对结构的影响，分析表明替换杆件的数量的增多能够提高地震控制的效果，但不是越多越好，要经过计算分析控制在一定的数量。     

Aptamer and its applications in neurodegenerative diseases

Aptamers are small single-stranded DNA or RNA oligonucleotide fragments or small peptides, which can bind to targets by high affinity and specificity. Because aptamers are specific, non-immunogenic and non-toxic, they are ideal materials for clinical applications. Neurodegenerative disorders are ravaging the lives of patients. Even though the mechanism of these diseases is still elusive, they are mainly characterized by the accumulation of misfolded proteins in the central nervous system. So it is essential to develop potential measures to slow down or prevent the onset of these diseases. With the advancements of the technologies, aptamers have opened up new areas in this research field. Aptamers could bind with these related target proteins to interrupt their accumulation, subsequently blocking or preventing the process of neurodegenerative diseases. This review presents recent advances in the aptamer generation and its merits and limitations, with emphasis on its applications in neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, transmissible spongiform encephalopathy, Huntington’s disease and multiple sclerosis.     

三角网格模型五轴加工刀轴矢量调整及优化

为消除全局干涉,提出了一种基于K-D树及刀具离散的高效刀轴矢量调整算法.算法首先以有限个点离散表示刀具,然后利用K-D树快速查找刀具的可能干涉点,并在此基础上计算调整后的刀轴矢量.为避免过大的刀轴矢量突变,提出一种分角度区域方法优化刀轴矢量.实例验证表明:算法能够高效实现全局干涉避免及刀轴矢量优化.     

Image separation using wavelet-complex shearlet dictionary

This paper presents a new method for image separation through employing a combined dictionary consisting of wavelets and complex shearlets. Because the combined dictionary sparsely represents points and curvilinear singularities respectively, the image can be decomposed into pointlike and curvelike parts as accurate as possible. The proposed method based on the geo- metric separation theory introduced by Donoho in 2005 shows that accurate geometric separation of the morphologically distinct fea- tures of points and curves can be achieved by l1 minimization. The experimental results show that the proposed method can not only be effective but also greatly reduce the computing time.     

聚讼与规范：经济犯罪概念的认定与特征的“限制”性释义

经济犯罪的概念虽被提出和使用很久,但至今仍未统一定论。我国的刑事政策决定了经济犯罪的客体,经济犯罪主要侵犯的客体是国家整体经济的秩序。本文在对域内外经济犯罪概念进行的聚讼与争鸣分析后,认为经济犯罪是指从事经济活动的自然人和法人在经济运行过程中,实施违反经济法规,侵害经济管理秩序和经济协调关系,情节严重,依法应当承担刑事责任的行为。经济犯罪概念的认定与特征的＂限制＂性释义取得规范,不仅易于了解经济犯罪的特殊性,也可使刑法的效能得到最大发挥。     

Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src

Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca²⁺ (Ca_V) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms whereby ApoCIII hyperactivates β cell Ca_V channels. We now demonstrate that ApoCIII increased Ca_V1 channel open probability and density. ApoCIII enhanced whole-cell Ca²⁺ currents and the Ca_V1 channel blocker nimodipine completely abrogated this enhancement. The effect of ApoCIII was not influenced by individual inhibition of PKA, PKC, or Src. However, combined inhibition of PKA, PKC, and Src counteracted the effect of ApoCIII, similar results obtained by coinhibition of PKA and Src. Moreover, knockdown of β1 integrin or scavenger receptor class B type I (SR-BI) prevented ApoCIII from hyperactivating β cell Ca_V channels. These data reveal that ApoCIII hyperactivates β cell Ca_V1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src.