Formation of proviruses in acute infection in vitro and in vivo

Summary Formation of DNA proviruses of RNA viruses, Sendai and Newcastle disease, was studied. DNA provirus of NDV was shown to be formed in mouse L-cells and Sendai DNA provirus in Ehrlich ascites carcinoma cells within 2–3 days post infection.     

Periodicity in body temperature in man

Summary Body temperatures and self-assessed mood scales were recorded for 7 weeks or more by male volunteers. Auto-correlations of temperatures from the 21 subjects show evidence of a significant peak at the 20-day-interval. The self-assessed measure of Alertness (from 18 of them) also shows some evidence of rhythmicity, at the 22-day-period.     

New intermediates in phaeomelanogenesis in vitro

Riassunto Mediante esperimenti in vitro, è stato accertato che i primi stadi della biosintesi delle feomelanine conducono alla formazione di derivati diidrobenzotiazinici, ai quali sono state assegnate le strutture III e IV.

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This investigation was supported by a grant from the Laboratorio di Chimica e Fisica per lo Studio delle Molecole di Interesse Biologico del C.N.R., Napoli.     

Hairiness in wool in relation to blood potassium types in Marwari sheep

Zusammenfassung Schafe mit geringem Kaliumgehalt im Blut haben an mehreren Körperstellen weniger markhaltige Haare als Tiere mit höherem K-Gehalt.     

Scientific inertia in animal-based research in biomedicine

Despite aspirations to substitute animal experimentation with alternative methods and recent progress in the area of non-animal approaches, such as organoïds and organ(s)-on-a-chip technologies, there is no extensive replacement of animal-based research in biomedicine. In this paper, I will analyse this state of affairs with reference to key institutional and socio-epistemic barriers for the development and use of non-animal approaches in the context of biomedical research in Europe. I will argue that there exist several factors that inhibit change in this context. In particular, there is what I call “scientific inertia”, i.e. a certain degree of conservatism in scientific practice regarding the development and use of non-animal approaches to replace animal experimentation. This type of inertia is facilitated by socio-epistemic characteristics of animal-based research in the life sciences and is a key factor in understanding the status quo in biomedical research. The underlying reasons for scientific inertia have not received sufficient attention in the literature to date because the phenomenon transcends traditional disciplinary boundaries in the study of animal experimentation. This paper addresses this issue and seeks to contribute to a better understanding of scientific inertia by using a methodology that looks at the interplay of institutional, epistemic, and regulatory aspects of animal-based research.     

Angiogenic activity in CSF in human malignancies

Summary Angiogenic activity, tested on the chorioallantoid membrane of the chicken embryo, was present in the CSF of patients with meningioma and glioblastoma and in patients with other malignancies with no clinical signs of CNS involvement.     

Distal axonopathy in streptozotocin diabetes in rats

We noted the earliest morphological changes in the motor endplates 8 weeks after the induction of streptozotocin diabetes in rats. Morphometric measurements showed reduced axonal areas of the lateral plantar and the sciatic nerves in the diabetic rats 28 but not 2 and 8 weeks after the experiment. These findings suggested distal axonopathy.     

Serum glycoprotein levels in athletes in training

Résumé Les sportifs examinés au repos, après plusieurs jours consécutifs d'entraînement ou de compétitions ont un niveau nettement plus élevé que le groupe de contrôle pour l'₁-antitrypsine, l'₂-HS-glycoprotéine, l'₂-macroglobuline, la transferrine, la céruloplasmine et le cuivre sériques. La signification biologique possible de ces faits est discutée.

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With support from the Deutsche Forschungsgemeinschaft and Kuratorium für Sportmedizin.

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Dozenten-Stipendiat der Alexander-von-Humboldt-Stiftung.     

Distal axonopathy in streptozotocin diabetes in rats

Summary We noted the earliest morphological changes in the motor endplates 8 weeks after the induction of streptozotocin diabetes in rats. Morphometric measurements showed reduced axonal areas of the lateral plantar and the sicatic nerves in the diabetic rats 28 but not 2 and 8 weeks after the experiment. These findings suggested distal axonopathy.     

Seasonal variations in vasopressin secretion in rats

Plasma vasopressin concentrations and vasopressin content in neurohypophysis in rats show seasonal variations; namely, high in summer and low in winter.