The effect of chloramphenicol analogs on protein biosynthesis in a cell-freeEscherichia coli B system

a aaa a aa aa a a E. coli aa, a aa aa a , a a aa - a .

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Laboratory of Biological Investigations.

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Laboratory for Chemistry of Antibiotics.     

A new synthetic method of coumestan derivatives

Zusammenfassung Die Synthese von 7-Hydroxy-5,6-dimethoxybenzofurano[3,2:3,4]coumarin aus 7,2-Dihydroxy-oder 7-Benzyloxy-2-hydroxy-4,5-dimethoxyisoflavon wird beschrieben.     

Fever produced in rabbits by N6, O2′-dibutyryl adenosine 3′, 5′-cyclic monophosphate

Zusammenfassung Die Injektion von N⁶-2-O-Dibutyryl-adenosin-3 5-monophosphat in den lateralen Hirnventrikel von Kaninchen führt zu einer langanhaltenden Fieberreaktion, was vermuten lässt, dass zyklisches Adenosin-35-monophosphat als weiterer Mediator in der Genese des Fiebers fungiert.     

The effect of protein biosynthesis inhibitors upon the development of cellular membranes hyperpolarization

( , , ) .     

Defensive steroids from a carrion beetle (Silpha americana)

Summary The defensive anal effluent discharged bySilpha americana in response to disturbance contains a mixture of steroids stemming from a glandular annex of the rectum. The compounds have been characterized as 15-hydroxyprogesterone (1, principal component), 5-pregnan-15-ol-3, 20-dione (2), 5-pregnan-3, 15-diol-20-one (3), 5-pregnan-7, 15-diol-3,20-dione (4), 5-pregnan-3, 7, 15-triol-20-one (5), 5-pregnan-16-ol-3,20-dione (6), and 5-pregnan-3, 16-diol-20-one (7), none previously found in insects. Bioassays with jumping spiders showed compounds1 and6 to be feeding deterrents at the 1 g level.Paper No. 78 of the series: Defense Mechanisms of Arthropods. Study supported by NIH (Grants AI-02908, AI-12020). We thank Maura Malarcher and Maria Eisner for excellent technical help, and the Squibb Institute of Medical Research for samples of authentic reference compounds.     

The syntheses of axillarin and its related compounds

Zusammenfassung Axillarin (5, 7, 3, 4-Tetrahydroxy-3,6-dimethoxyflavon). 5,3,4-Trihydroxy-3,6,7-trimethoxyflavon und 5,7,3,4-Tetrahydroxy-3,8-dimethoxyflavon wurden synthetisiert.     

Synthesis and pharmacological properties of [1-N4-dimethyl-asparagine]-angiotensin II

Summary [1-N⁴-Dimethyl-asparagine]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue gave rat blood pressure about 70% relative potency to Hypertensin (Ciba). Rabbit aorta strips gave intrinsic activity _E=1, a PD₂ of 6.92±0.09 and an affinity relative to [Asn¹]-angiotensin II of 6.5%.The editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. — Les auteurs sont seuls responsables des opinions exprimées dans ces brèves communications. — Für die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich. — Per le brevi comunicazioni è responsabile solo l'autore. — . — Solo los autores son responsables de las opiniones expresadas en estas comunicationes breves.Acknowledgment. The authors wish to express their appreciation to Dr Emanuel Escher, School of Medicine, Centre Hospitalier Universitaire, Sherbrooke, Quebec, for his help in providing the biological data and critical comments.     

Isoforms of baker's yeast transketolase

. .     

Chromosomes and some issues of the evolution of the ground squirrel genusCitellus (Rodentia: Sciuridae)

Citellus (s. str.) relictus, C. dauricus C. pygmaeus (2=36, NF=72). . (Colobotis) erythrogenys . fulvus -. . (Urocitellus) undulatus (2n=32, NF=64) . columbianus. Citellus, , Citellus, . , .     

The stimulating action of gastrin pentapeptide,histamine and cyclic adenosine 3′,5′-monophosphate on carbonic anhydrase in rat stomach

, 3,5- . , , , , 3,5-.

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With the technical assistance ofYu. M. Konstantinov andT. V. Zymonina.     

G-band patterns as chromosomal markers,and the interpretation of chromosomal evolution in wild sheep (Ovis)

- . Ovis musimon (2n=54) O. orientalis (2n=54) - - -O. canadensis mexicana (2n=54) O. musimon x O. canadensis ₁₂ - . ₂ 27 . - .

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Supported by National Science Foundation Grant no. GB 32114X and the Sprague Foundation. We thank Dr. T. C. Hsu for assistance in making the chromosome preparations and for advice and encouragement. The Trustees of the Rachelwood Wildlife Research Preserve generously allowed the biopsy of specimens of their custody. Mr.Arthur Popham kindly provided the specimens from Iran while Dr.R. M. Robinson obtained biopsies from the desert sheep.     

Interaction of 1-anilino-8-naphthalene sulfonate with yeast glyceraldehyde-3-phosphate dehydrogenase

1--8- () -3- () . []:[]<10:1 140 000 3±1 5×10^–5 . , i 5×10^–5 –6×10^–5 M. , .     

Potential juvenile hormone analogues containing piperidine ring: Synthesis and biological assay on insects

Summary Some compounds containing piperidine rings have been synthesized, and submitted to biological tests on insects for their hormonal activity on pupae ofTenebrio molitor L. andBombyx mori L. Some of them display a hormoneanalogue or toxic activity.The editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. — Les auteurs sont seuls responsables des opinions exprimées dans ces brèves communications. — Für die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich. — Per le brevi comunicazioni è responsabile solo l'autore. — . — Solo los autores son responsables de las opiniones expresadas en estas comunicationes breves.This research has been supported by the Italian National Research Council (CNR) special ad hoc program Fitofarmaci e Fitoregolatori, Subproject. 7.Acknowledgments. We thank Prof. G. Jommi for helpful discussions related to this and previous articles on the same subject.     

Induced seed protein mutant of barley

. 51%. () 29% 9% - . .

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Seed samples may be obtained upon application toH. Doll.     

Protein biosynthesis and hyperpolarization of cells

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Some functional characteristics of the electroreceptors (the ampullae of lorenzini) of elasmobranchs

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Normalization by nucleotides of impairments in deamination of nitrogenous compounds in liver of tumor-bearing mice

-2 (3)--3- - .     

Unique occurrence of fenchol in the animal kingdom

Summary (–)--Fenchol, a compound occurring in plants but not heretofore reported to occur in an animal product, was isolated from volatiles released by adult male Mediterranean fruit flies,Ceratitis capitata Wiedemann, with the male's previously identified sex pheromones. It neither attracts females nor synergizes the pheromones, and its function remains unknown.The editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. — Les auteurs sont seuls responsables des opinions exprimées dans ces brèves communications. — Für die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich.—Per le brevi comunicazioni è responsabile solo l'autore. — . — Solo los autores son responsables de las opiniones expresadas en estas communicationes breves.Mention of a proprietary product in this paper does not constitute a recommendation or an endorsement of the product by the US Department of Agriculture.Acknowledgments. We thank C. Harding for assistance with extractions and fractionations, R.M. Waters for spectral analyses, M.S. Fujimoto and H. Higa for collecting the volatiles and conducting laboratory and cage bioassays, and T. Urago and S. Nakagawa for conducting the field tests.     

Topochemical approach to the structure-activity relation. Retroenantio-Gly5,10-gramicidin S

, . , -Gly^5,10- , Gly^5,10- .     

Effect of urochordamines on larval metamorphosis of ascidians

Two pteridine-containing bromophysostigmine alkaloids, urochordamine A and B, which were isolated from ascidians as larval metamorphosis promoters, were converted to more polar compounds, urochordamine A and B, respectively, when left standing in protic solvents. These four compounds promoted larval metamorphosis of the ascidianHalocynthia roretzi in the order A>A>B>B, and induced metamorphosis of the pediveliger larvae of the musselMytilus edulis galloprovincialis.