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1.
用常规病理学方法 ,对人工感染 2 .4× 10 5个混合球虫卵囊的雏鸡进行病理解剖学和病理组织学观察。眼观所见显著病变为盲肠肿胀、充血、出血 ;病理组织学变化的主要特征为盲肠卡他性或出血性、坏死性肠炎 ,并有大量不同发育阶段的球虫寄生 ;其次是十二指肠和空肠 ,表现粘膜上皮细胞肿胀、变性、坏死和血液循环障碍 ,在十二指肠也有少量不同发育阶段的球虫寄生。心、肝、脾、肾的实质细胞呈轻度的颗粒变性或水泡变性  相似文献   

2.
以64例自然感染发病的犬瘟热病犬为研究对象,在系统观察临床症状及其演变过程的同时,施以抗病毒、抗菌和支持疗法为主的治疗方案,记录治疗方案对临床病程的影响,并对病死犬或以安乐死术处死犬进行系统的尸体剖解和病理组织学检查.结果表明,在成都地区,感染犬瘟热病毒的病犬早期以呼吸系统和消化系统症状为主,后期出现抽搐和运动失调等神经症状;病理损害以卡他性、化脓性支气管炎、化脓性支气管肺炎及间质性肺炎,卡他性或出血性胃肠炎,脑萎缩,脑积水,中枢神经系统脱髓鞘及上皮细胞、神经细胞和胶质细胞内病毒性包涵体形成为特征.  相似文献   

3.
犬瘟热是由犬瘟热病毒引起的犬和肉食目中许多动物的一种高度接触传染性疾病,以复相热、急性卡他性鼻炎、支气管炎、卡他性肺炎、严重胃肠炎和神经症状为特征.该病常继发细菌性感染.现本人结合近几年的接诊经验,谈谈犬瘟热的流行病学、发病机理、临床症状及病理变化、诊断及防治.  相似文献   

4.
巴氏杆菌病使养兔业遭受重大损失,本传染病呈现急性或慢性经过。该病临床症状呈多样性:鼻灸,卡他性或卡他性化脓性肺炎,胃肠道疾患,子宫炎,皮下脓肿或关节炎。病理解剖时呼吸器官呈纤维素性—坏死性过程,鼻腔内有粘液脓性或脓性分泌物非  相似文献   

5.
对一起鸡传染病进行了病原鉴定并对其自然死亡的46例蛋鸡进行了临床病理学研究,结果表明,本起鸡病为A型禽流感,H5N1亚型,属高致死性(HPAI);急性热性出血性败血症;急性坏死性胰腺炎;非化脓性脑炎;卡他性上呼吸道炎;卡他性、间质性肺炎。  相似文献   

6.
赵太革  张永 《科技信息》2009,(33):T0361-T0361,T0365
奶牛乳房炎是乳房受到物理、化学、微生物等致病因子刺激所发生的一种炎性变化。乳房炎的分类方法较多,有以病原、病理、病程、部位以及临床症状分的,有以乳汁细胞数、乳房和乳汁有无肉跟可见变化分的。现临床上较为适用的分法为:非临床型或亚临床型乳房炎、临床型乳房炎、慢性乳房炎:临床型乳房炎根据炎症性质还可分为:浆液性炎、卡他性炎、纤维蛋白性炎、化脓性炎、出血性炎。  相似文献   

7.
徐长卿,性味辛温,无毒,归肝肾经,有解毒消肿、祛风通络、止痛止痒之功效.临床上,应用单方、配伍治疗多种疾病均有良好疗效.用量一般在10~30 g之间,内服外用均可.且用量不受明显限制,可用到60 g.可用于周围性神经麻痹,顽固性变应性皮肤病,卡他性结膜炎,男科,妇科,内科等疾病的治疗,是一味用途广泛的良药.  相似文献   

8.
春秋季耳鼻喉科疾病种类繁杂,但门诊病人则以急慢性咽炎;急慢性鼻炎、鼻窦炎;急性卡他性中耳炎、化脓性中耳炎及扁桃体炎、喉炎为主。次为过敏性鼻炎、外耳道炎、口扁周围脓肿等。  相似文献   

9.
H5N1亚型禽流感的研究   总被引:1,自引:0,他引:1  
对发生在通辽地区的一起鸡的传染病进行了病原及其型的鉴定、流行病学调查、临床病理学研究,同时采取了综合性防制措施,结果为:该起鸡病为A型禽流感(Avian Influenza AI)H5N1亚型、为高致死性(HPAI)、极具传染性.临床病理学表现为急性热性出血性败血症、急性坏死性胰腺炎、非化脓性脑炎、卡他性上呼吸道炎、卡他性间质性肺炎及多个器官变质性坏死性炎.由于及时采取了隔离封锁,扑杀、消毒、无害化处理,疫情跟踪监测和免疫接种等有效的综合性防制措施,而使该传染病就地扑灭,疫情未造成扩散蔓延.  相似文献   

10.
鳖嗜水气单胞菌败血症的病理学观察   总被引:6,自引:0,他引:6  
对鳖嗜水气单胞菌感染所致鳖败血症的病理学观察表明,其主要病理变化是脾肿胀、充血、出血;肝肿大,出血明显,肝细胞颗粒变性,空泡变性;肾小管上皮肿胀,颗粒变性,坏死;肺淤血;卡他性肠炎.  相似文献   

11.
家兔消化器官肥大细胞的定位研究   总被引:5,自引:0,他引:5  
采用甲苯胺蓝染色法,对5只健康家兔消化器官肥大细胞(Mast cell,MC)进行定位,光镜观察其分布特点。结果表明,健康家兔盲肠、空肠、12指肠、食道以及胃肥大细胞主要分布于粘膜固有层或粘膜下层结缔组织内,而肝脏与胰腺等实质消化器官MC主要分布于被膜或裨细胞间结缔组织内。其中,粘膜MC靠近一些分泌型细胞分布,而结缔组织肥大细胞有围绕血管,神经或腺管分布的趋向。  相似文献   

12.
Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity   总被引:45,自引:0,他引:45  
Diefenbach A  Jensen ER  Jamieson AM  Raulet DH 《Nature》2001,413(6852):165-171
Natural killer (NK) cells attack many tumour cell lines, and are thought to have a critical role in anti-tumour immunity; however, the interaction between NK cells and tumour targets is poorly understood. The stimulatory lectin-like NKG2D receptor is expressed by NK cells, activated CD8+ T cells and by activated macrophages in mice. Several distinct cell-surface ligands that are related to class I major histocompatibility complex molecules have been identified, some of which are expressed at high levels by tumour cells but not by normal cells in adults. However, no direct evidence links the expression of these 'induced self' ligands with tumour cell rejection. Here we demonstrate that ectopic expression of the murine NKG2D ligands Rae1beta or H60 in several tumour cell lines results in potent rejection of the tumour cells by syngeneic mice. Rejection is mediated by NK cells and/or CD8+ T cells. The ligand-expressing tumour cells induce potent priming of cytotoxic T cells and sensitization of NK cells in vivo. Mice that are exposed to live or irradiated tumour cells expressing Rae1 or H60 are specifically immune to subsequent challenge with tumour cells that lack NKG2D ligands, suggesting application of the ligands in the design of tumour vaccines.  相似文献   

13.
J R Strazdis  V L MacKay 《Nature》1983,305(5934):543-545
Saccharomyces cerevisiae cells of a and alpha mating types constitutively secrete cell-specific peptide mating pheromones. a-Factor is secreted by a cells and acts on alpha cells, while alpha-factor is secreted by alpha cells and acts on a cells. Confirming preliminary studies, we demonstrate here that cultures of a cells contain higher than constitutive levels of a-factor activity when grown with alpha cells or alpha-factor. This induction of a-factor may result from increased synthesis or increased secretion of a-factor, as opposed to modification or stabilization of preexisting a-factor, as part of the a cell response to alpha-factor, as an a ste2 mutant (which cannot respond to alpha-factor) is not induced by alpha-factor. In mixed cultures inoculated with equal numbers of a cells and alpha cells, a cells predominate by stationary phase. Thus, a series of sequential interactions between a and alpha cells may be involved in establishing optimal hormone concentrations and cell ratios for conjugation.  相似文献   

14.
Accessory cell-dependent selection of specific T-cell functions   总被引:1,自引:0,他引:1  
G Ramila  P Erb 《Nature》1983,304(5925):442-445
Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lines of macrophage or B-cell origin were shown to act as accessory cells in certain assays. We showed previously that normal peritoneal exudate macrophages (PEC) induced both T-cell proliferation as well as T-cell help, whereas various Ia+ tumour lines of macrophage or B-cell origin, although stimulating antigen-specific T-cell proliferation, did not significantly activate T-cell help. We report here that during the initial T-cell activation in vitro accessory cells (PEC or Ia+ tumour cells) select particular T cells to express previously determined functions. Moreover, some tumour cell lines induce suppressor T cells which inhibit helper activity.  相似文献   

15.
Cell lineage analysis reveals multipotency of some avian neural crest cells   总被引:6,自引:0,他引:6  
M Bronner-Fraser  S E Fraser 《Nature》1988,335(6186):161-164
A major question in developmental biology is how precursor cells give rise to diverse sets of differentiated cell types. In most systems, it remains unclear whether the precursors can form many or all cell types (multipotent or totipotent), or only a single cell type (predetermined). The question of cell lineage is central to the neural crest because it gives rise to numerous and diverse derivatives including peripheral neurons, glial and Schwann cells, pigment cells, and cartilage. Although the sets of derivatives arising from different populations of neural crest cells have been well-documented, relatively little is known about the developmental potentials of individual neural crest cells. We have iontophoretically microinjected the vital dye, lysinated rhodamine dextran (LRD) into individual dorsal neural tube cells to mark unambiguously their descendants. Many of the resulting labelled clones consisted of multiple cell types, as judged by both their location and morphology. Cells as diverse as sensory neurons, presumptive pigment cells, ganglionic supportive cells, adrenomedullary cells and neural tube cells were found within individual clones. Our results indicate that at least some neural crest cells are multipotent before their departure from the neural tube.  相似文献   

16.
Does T-cell tolerance require a dedicated antigen-presenting cell?   总被引:15,自引:0,他引:15  
P Matzinger  S Guerder 《Nature》1989,338(6210):74-76
Almost 30 years ago Burnet proposed that the immune system maintained self-tolerance by deleting autoreactive lymphocytes. Recently it has become clear that for T cells this step occurs in the thymus, where developing T cells first express their antigen-specific receptors. Here a T-cell which encounters its antigen disappears--if it is not dead, it at least stops expressing its receptors. In the periphery by contrast, encounter with antigen leads to activation and proliferation of the responding T-cell. There are two possible explanations for this difference. Either the antigen-presenting cells in the thymus are different from those in the periphery and instead of producing positive signals they directly or indirectly kill the thymocytes; or the T cells themselves are different, and like immature B cells, may die after encounter with antigen. We tested the first possibility and found that dendritic cells from spleen, which are the most potent activators of mature T cells, are also the most potent inactivators of young developing T cells. Thus it is not the antigen-presenting cell which determines whether a T-cell responds or dies, but the T-cell itself or its thymic environment.  相似文献   

17.
以威廉环毛蚓为实验材料,对其神经内分泌系统的显微、亚显微结构及其对体表水交换的影响作了初步研究.通过大量的实验,说明在威廉环毛蚓的中枢神经系统中存在三种不同类型的细胞,即A、B和C三种细胞.A细胞数量最多,位于脑神经节、咽下神经节和腹神经索中.B细胞主要位于咽下神经节.C细胞主要位于咽下神经节和腹神经索中.神经内分泌活动与季节有关,A细胞和C细胞的分泌活动随季节变化而不同,B细胞的内分泌活动受季节的影响不大.蚯蚓体表的水交换受神经内分泌调控,这种因子仅存在于脑神经节内.  相似文献   

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