2-(2H-苯并吡喃-2-酮-3基)-5-取代硫醚(砜)-1,3,4-噁二唑衍生物的合成

以水杨醛和丙酮为起始原料,合成了4个2-(2H-苯并吡喃-2-酮-3基)-5-取代硫醚-1,3,4-噁二唑衍生物.目标化合物较佳合成工艺条件为:DMF为溶剂,K2CO3为缚酸剂,反应温度为65° C,反应时间为4h,物料投料n[5-巯基2-(2H-苯并吡喃-2-酮-3基)-1,3,4-噁二唑]∶(卤代烃)=1.0∶1.2.产物经1H NMR,13C NMR,IR以及元素分析确证.     

室温有机催化1,3-偶极环加成反应合成苯并吡喃[4,3-b]吡咯类化合物

该文设计合成了(1R)-2,2'-二羟基-N,N'-双((2-甲基环己基)氨基甲硫酰基)[1,1'-联萘]-3,3'-二甲酰胺(1a)等4种催化剂,并将其用于不对称催化亚甲胺叶里德的1,3-偶极环加成反应合成苯并吡喃[4,3-b]吡咯化合物.实验结果表明:在室温下,以物质的量分数为10%的1d作为催化剂,以CH₂Cl₂为溶剂,苯并吡喃[4,3-b]吡咯化合物的产率(88%)较高,且产物具有较高(86%)的对映选择性.该反应具有环境友好、反应条件温和、催化剂经济易得和操作简单等优点.     

新型查尔酮荧光探针的合成及F-的识别

通过羟醛缩合反应合成了一种新的苯并吡喃和苯酚结构的查尔酮荧光探针C,其结构用~1H NMR,~(13)C NMR和元素分析的手段进行了表征确认.利用荧光光谱法研究了探针C在CH_3CH_2OH/H_2O的混合溶液中对不同阴离子的荧光行为.结果表明探针C对氟离子具有优异的选择性和灵敏度,与氟离子形成的氢键显示了明显的荧光响应.Job’s Plot曲线表明,探针C与F~-的配位比是1∶1.最低检测限可达2.64×10~(-5) mol/L.     

热致变色螺吲哚啉苯并吡喃-6′-亚甲基巴比土酸的合成

利用６′－醛基螺吲哚啉苯并吡喃与巴比土酸或１，３－二乙基巴比土酸的反应，合成了螺吲哚啉苯并吡喃－６′－亚甲基巴比土酸和螺吲哚啉苯并吡喃－６′－亚甲基双（１，３－二乙基巴比土酸），经元素分析、１ＨＮＭＲ等确定了它们的分子结构和组成。发现它们具有热致变色作用，并据此试制了热致变色油墨。     

2,2-二甲基-3-羟基-6-甲氧酰基苯并吡喃的首次全合成

天然 3-羟基苯并吡喃类化合物具有重要的生物活性 ,其合成已引起了许多化学家的关注 [1] .Chen等[2 ] 报道 Kuhistanol D ( 1 )对酯多糖刺激人体外围单核细胞具有明显的抑制作用 ,但其合成研究尚未见报道 .为了探讨这类化合物的合成方法及其生物活性与结构的关系 ,我们开展其类     

一种含苯并吡喃潜在染料的合成及晶体结构

合成了一个含苯并吡喃基团的鲜红色化合物2 N'-{1-[7-(二乙氨基)-2-氧-2H-苯并二氢吡喃-3-]亚乙基}苯甲酰肼.单晶X-衍射分析结果表明:化合物2属于斜方晶系,P2(1)2(1)2空间群.酰胺键共振成两性离子结构使分子内形成两个N—H…O氢键,这种分子内氢键环使得两侧苯环和苯并吡喃环几乎共平面,二面角仅仅为3.0(1)度,整个分子呈平面结构,令其具有作为染料分子的潜力.     

两种具有杀线虫活性异戊烯基黄烷酮的全合成

以廉价的苯甲醛、对羟基苯甲醛和2-羟基苯乙酮为起始原料,经过C-异戊烯基化、酚羟基保护、羟醛缩合、催化环化、去保护基等步骤,合成了天然产物（±）-2,3-二氢-2-苯基-8-（3-甲基-丁基-2-烯基）-4H-1-苯并吡喃-4-酮及（±）-2,3-二氢-2-（4-羟苯基）-8-（3-甲基-丁基-2-烯基）-4H-1-苯并吡喃-4-酮,总收率分别为20%和16.3%.所有新化合物的结构都经过1HNMR,IR,MS确认.     

奈必洛尔中间体的不对称合成

(S,R,R,R)-奈必洛尔是一种新型、强效的β1-肾上腺素能受体阻滞剂降压药物.采用氧化/Wittig烯化一锅煮反应和Sharpless不对称环氧化/环化一锅煮反应,经八步反应,不对称合成出(S,R,R,R)-奈必洛尔的两个关键中间体1-[6-氟-(2S)-3,4-二氢-2H-2-苯并吡喃]-(1R)-1,2-乙二醇和1-[6-氟-(2R)-3,4-二氢-2H-2-苯并吡喃]-(1S)-1,2-乙二醇.该合成路线工艺简单,单步反应产率高,八步反应总收率达19%.     

用于Aβ标记的新型近红外荧光染料BPAD-2的制备与生物学评价

以邻羟基苯乙酮为初始原料,通过缩合反应合成了2-{2-[2-(4-羟基苯基)乙烯基]苯并吡喃-4-}-丙二腈(BPAD-2),并通过1 H-NMR与MS确认结构;考察所制备探针的荧光光谱;通过荧光染色考察探针的Aβ结合标记;通过荧光成像考察探针的血脑屏障通过能力.结果表明BPAD-2的最大发射波长为658nm;BPAD-2荧光标记的Aβ呈亮红色;BPAD-2尾静脉注入正常小鼠后脑内显示荧光信号,10min内荧光强度达到最高,随着时间延长荧光强度逐渐减弱.说明苯并吡喃结构的BPAD-2具有近红外荧光性质,并显示良好的Aβ荧光标记和血脑屏障通过能力.     

吲哚啉螺吡喃化合物的合成及光致变色性质研究

合成了6-硝基-1,′3,′3′-三甲基吲哚啉螺苯并吡喃,通过红外光谱和元素分析确证其结构,并研究了闭环体与开环体的光致变色性能,解释了在不同溶剂介质中紫外吸收光谱的溶剂效应,并比较褪色反应速率常数的差异.     

Characterization of Ordovician carbonate reservoirs, southeastern Saskatchewan, Canada

The discovery of the prolific Ordovician Red River reservoirs in 1995 in southeastern Saskatchewan was the catalyst for extensive exploration activity which resulted in the discovery of more than 15 new Red River pools. The best yields of Red River production to date have been from dolomite reservoirs. Understanding the processes of dolomitization is, therefore, crucial for the prediction of the connectivity, spatial distribution and heterogeneity of dolomite reservoirs.The Red River reservoirs in the Midale area consist of 3～4 thin dolomitized zones, with a total thickness of about 20 m, which occur at the top of the Yeoman Formation. Two types of replacement dolomite were recognized in the Red River reservoir: dolomitized burrow infills and dolomitized host matrix. The spatial distribution of dolomite suggests that burrowing organisms played an important role in facilitating the fluid flow in the backfilled sediments. This resulted in penecontemporaneous dolomitization of burrow infills by normal seawater. The dolomite in the host matrix is interpreted as having occurred at shallow burial by evaporitic seawater during precipitation of Lake Almar anhydrite that immediately overlies the Yeoman Formation. However, the low δ18O values of dolomited burrow infills (-5.9‰～ -7.8‰, PDB) and matrix dolomites (-6.6‰～ -8.1‰, avg. -7.4‰ PDB) compared to the estimated values for the late Ordovician marine dolomite could be attributed to modification and alteration of dolomite at higher temperatures during deeper burial, which could also be responsible for its 87Sr/86Sr ratios (0.7084～0.7088) that are higher than suggested for the late Ordovician seawaters (0.7078～0.7080). The trace amounts of saddle dolomite cement in the Red River carbonates are probably related to "cannibalization" of earlier replacement dolomite during the chemical compaction.     

A computer generator for randomly layered structures

AcomputergeneratorforrandomlylayeredstructuresYUJia shun1,2,HEZhen hua2(1.TheInstituteofGeologicalandNuclearSciences,NewZealand;2.StateKeyLaboratoryofOilandGasReservoirGeologyandExploitation,ChengduUniversityofTechnology,China)Abstract:Analgorithmisintrod…     

An Index mechanism for multi-scale view in spatial databases

There are numerous geometric objects stored in the spatial databases. An importance function in a spatial database is that users can browse the geometric objects as a map efficiently. Thus the spatial database should display the geometric objects users concern about swiftly onto the display window. This process includes two operations:retrieve data from database and then draw them onto screen. Accordingly, to improve the efficiency, we should try to reduce time of both retrieving object and displaying them. The former can be achieved with the aid of spatial index such as R-tree, the latter require to simplify the objects. Simplification means that objects are shown with sufficient but not with unnecessary detail which depend on the scale of browse. So the major problem is how to retrieve data at different detail level efficiently. This paper introduces the implementation of a multi-scale index in the spatial database SISP (Spatial Information Shared Platform) which is generalized from R-tree. The difference between the generalization and the R-tree lies on two facets: One is that every node and geometric object in the generalization is assigned with a importance value which denote the importance of them, and every vertex in the objects are assigned with a importance value,too. The importance value can be use to decide which data should be retrieve from disk in a query. The other difference is that geometric objects in the generalization are divided into one or more sub-blocks, and vertexes are total ordered by their importance value. With the help of the generalized R-tree, one can easily retrieve data at different detail levels.Some experiments are performed on real-life data to evaluate the performance of solutions that separately use normal spatial index and multi-scale spatial index. The results show that the solution using multi-scale index in SISP is satisfying.     

海南岛地体及其毗邻陆缘晚中生代—新生代古地磁研究和构造演化

本文叙述了对海南岛及其毗邻大陆边缘白垩纪到第四纪地层岩石进行古地磁研究的全部工作过程。通过分析岩石中剩余磁矢量的磁偏角及磁倾角的变化,提出海南岛白垩纪以来经历的构造演化模式如下:早期伴随顺时针旋转而向南迁移,后期伴随逆时针转动并向北运移。联系该地区及邻区的地质、地球物理资料,对海南岛上述的构造地体运动提出以下认识:北部湾内早期有一拉张作用,主要是该作用使湾内地壳显著伸长减薄,形成北部湾盆地。从而导致了海南岛的早期构造运动,而海南岛后期的构造运动则主要是受南海海底扩张的影响。海南地体运动规律的阐明对于了解北部湾油气盆地的形成演化有重要的理论和实际意义。     

Exciton Seebeck in Molecular Systems

Various applications relevant to the exciton dynamics,such as the organic solar cell,the large-area organic light-emitting diodes and the thermoelectricity,are operating under temperature gradient.The potential abnormal behavior of the exicton dynamics driven by the temperature difference may affect the efficiency and performance of the corresponding devices.In the above situations,the exciton dynamics under temperature difference is mixed with     

Achieving Unusual States of Matter Under High Pressure

The elongation method,originally proposed by Imamura was further developed for many years in our group.As a method towards O(N)with high efficiency and high accuracy for any dimensional systems.This treatment designed for one-dimensional(ID)polymers is now available for three-dimensional(3D)systems,but geometry optimization is now possible only for 1D-systems.As an approach toward post-Hartree-Fock,it was also extended to     

《Chinese Science Bulletin》SUBJECT INDEX TO VOLUME 59(2014)

正~~     

An on-line scaling method for improving scalability of a database cluster

The explosive growth of the Internet and database applications has driven database to be more scalable and available, and able to support on-line scaling without interrupting service. To support more client's queries without downtime and degrading the response time, more nodes have to be scaled up while the database is running. This paper presents the overview of scalable and available database that satisfies the above characteristics. And we propose a novel on-line scaling method. Our method improves the existing on-line scaling method for fast response time and higher throughputs. Our proposed method reduces unnecessary network use, i.e. , we decrease the number of data copy by reusing the backup data. Also, our on-line scaling operation can be processed parallel by selecting adequate nodes as new node. Our performance study shows that our method results in significant reduction in data copy time.     

An improved R-tree based on childnode''s probability

R-Tree is a good structure for spatial searching. But in this indexing structure,either the sequence of nodes in the same level or sequence of traveling these nodes when queries are made is random. Since the possibility that the object appears in different MBR which have the same parents node is different, if we make the subnode who has the most possibility be traveled first, the time cost will be decreased in most of the cases. In some case, the possibility of a point belong to a rectangle will shows direct proportion with the size of the rectangle. But this conclusion is based on an assumption that the objects are symmetrically distributing in the area and this assumption is not always coming into existence. Now we found a more direct parameter to scale the possibility and made a little change on the structure of R-tree, to increase the possibility of founding the satisfying answer in the front sub trees. We names this structure probability based arranged R-tree (PBAR-tree).     

Integrating GIS Web services based on mediating architecture

The geographic information service is enabled by the advancements in general Web service technology and the focused efforts of the OGC in defining XML-based Web GIS service. Based on these models, this paper addresses the issue of services chaining,the process of combining or pipelining results from several interoperable GIS Web Services to create a customized solution. This paper presents a mediated chaining architecture in which a specific service takes responsibility for performing the process that describes a service chain. We designed the Spatial Information Process Language (SIPL) for dynamic modeling and describing the service chain, also a prototype of the Spatial Information Process Execution Engine (SIPEE) is implemented for executing processes written in SIPL. Discussion of measures to improve the functionality and performance of such system will be included.