共查询到20条相似文献,搜索用时 78 毫秒
1.
通过3甲氧甲酰基4羟基2甲基2H1 ,2苯并噻嗪1 ,1二氧化物与芳胺的胺解反应,合成了6 个新的3芳胺基甲酰基4羟基2甲基2H1 ,2苯并噻嗪1 ,1二氧化物,产物的结构通过红外、核磁及元素分析得到确证. 相似文献
2.
通过 3取代4氨基5巯基1,2,4三唑与卤代烃之间的亲核取代反应合成了 12 种含烷硫(芳硫)基的1,2,4三唑类衍生物,结构经1 H N M R 及元素分析而确证,并对所合成的化合物进行了初步的生物活性测试,结果表明部分化合物表现出一定的除草活性和杀菌活性 相似文献
3.
用顺式2丁烯1,4二醇与碘甲烷反应合成顺式1,4二甲氧基2丁烯以及通过选择性还原2丁炔1,4二醇得到反式2丁烯烯1,4二醇,后者与碘甲烷反应得到反1,4二甲氧基2丁烯 相似文献
4.
该文采用亚硫酸氢钠加成法从紫苏油中单离出紫苏醛,并以此为原料,通过肟化反应合成了超级甜味剂1,8对艹孟二烯7肟.文中对合成工艺的最佳技术条件进行了报导. 相似文献
5.
固液相转移催化条件下,合成了10个1芳氧基乙酰基4邻硝基苯甲酰基氨基硫脲.通过元素分析和红外光谱确定了其结构. 相似文献
6.
从 1o乙酰基2,3,5三o苯甲酰基4溴β D呋喃核糖出发,在溴化汞催化作用下,合成了 3 个 4取代的核苷化合物,其中 2 个化合物未见文献报道。 相似文献
7.
本文报告了γ(4,5二苯基2叩恶唑基)丁酸的合成.由于使用了吡啶催化剂,合成的总产率比文献值〔1〕提高了17%.并给出了产物及中间体的物理常数和光谱数据,对中间体合成的最佳反应条件进行了研究 相似文献
8.
N-取代芳基-3-羟基-2-乙基-4-吡啶酮的合成和结构 总被引:1,自引:1,他引:0
路再生 《徐州师范大学学报(自然科学版)》1998,(1)
由3羟基2乙基4吡喃酮和系列芳胺用“一锅”法合成了五种N取代芳基吡啶酮.测定了3d的晶体结构,晶体属三斜晶系,P1-空间群,晶胞参数a=7.306(1),b=10.351(1),c=17.321(2);α=86.25°,β=78.44°,γ=71.92°,V=1219.9(2)3,Z=4,Dc=1.335g·cm-3. 相似文献
9.
报道了一类用简便方法合成的4′(ω羧基烷基)苯并15冠5(LH)萃取K+的性能研究.考察了萃取剂LH的羧基与冠环之间桥链长短、萃取溶剂、pH值及K+的配对阴离子对分配比(萃取率)的影响,讨论了溶液中3种配合物KL的形成机理.结果表明,一定pH值下生成的1∶1型配合物KL中羧基与冠环发生了协同配位. 相似文献
10.
在干燥的氮气氛保护下,首次合成了9种稀士与3苯基5(呋喃2)吡唑啉二硫代甲酸配合物RE(S2CNC13H11NO)Cl2(RE=Gd-Lu,Y).通过元素分析、电导测定、红外光谱、差热分析对其进行了表征,结果表明配体是通过二个硫原子和呋喃环上的一个氧原子与稀土配位的 相似文献
11.
A convenient method to synthesize substituted 2-(2′-hydroxyphenyl) benzimidazoles is reported. Six title compounds have been
synthesized by the reaction of salicylic acid and 4-substituted0-phenylenediamine in the presence pyridine-POCl3. Three compounds were tested as plant virucide against tobacco mosaic virus and they exhibited some activities.
Supported by the National Natural Science Foundation of China, and National Laboratory of Elemento Organic Chemistry of Naikai
University
Huang Xiaoling: born in 1938, Professer 相似文献
12.
微波辐射下2-芳基取代苯并咪唑的合成 总被引:1,自引:0,他引:1
报道了以KHSO4为促进剂,在微波辐射下通过邻苯二胺与各种芳醛的缩合反应,较高产率合成了2-芳基取代苯并咪唑.该合成方法具有条件温和、操作简便、产率高、选择性良好、反应时间短等优点. 相似文献
13.
目的基于TiO2光催化性能的染料敏化改性,采用噻吩醛和邻苯二胺缩合反应,合成1-(2-噻吩亚甲基)-2-(2-噻吩基)苯并咪唑及其配合物。方法在稀土金属盐模板剂的作用下,合成得到了1-(2-噻吩亚甲基)-2-(2-噻吩基)苯并咪唑。结果合成了目标产物及其相应的配合物,并且通过单晶结构进行结构表征,用元素分析,红外,热重,固体荧光等进行性质表征。结论在配体合成方法上有一定的创新和突破,该制备方法简便易行,且产物较纯,无副产物,产率高,没有环境污染。 相似文献
14.
The substituent effects in the Birch reduction reaction of substituted benzenes are discussed. A nonplanar^boat-form conformation is suggested for the benzene radical union formed by the transfer of an electron to a substituted benzene-molecule. In this conformation the 1,4 -dienyl radical union has two double bonds isolated,the negative charge is localized on po-sion 6 and the. single electron is on position 3.the farthest position from the negative charge, when the substituent is electron-withdrawing. Both alkyl and alkoxy groups are considered to be electron-withdrawing. These sub-stituents should be activating groups for their inductive effect. The reaction rate decreasing of alkyl benzenes may be caused by reasons other than electronic effect. The reduction of benzole acid and. benzamide, in which 1,4-dihydro benzenes are obtained,is considered to be an exceptional example,in which an extra stabilized Y-aromatic radical union may be involved. 相似文献
15.
Search for new antiphytovirucides 总被引:3,自引:0,他引:3
The lead compound of substituted 2-(4′-hydroxyphenyl)benzimidazoles were modified by phosphorylation sulfonation and carboxymethylation.
The benzimidazoloamidophosphate (6) (7) have better activity against tobacco mosaic virus (TMV). The benzimidazolophenoxyacetic
acid, phenoxysulfonic acid containing trifluoromethyl, and nitro group have 77%≈85% efficiency for wheat rust disease.
Supported by the National Natural Science Foundation of China and National Laboratory of Elemento Organic Chemistry Nankai
University
Qu Fanqi: born in 1952, Associate professor 相似文献
16.
Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase 总被引:31,自引:0,他引:31
E Fellenius T Berglindh G Sachs L Olbe B Elander S E Sj?strand B Wallmark 《Nature》1981,290(5802):159-161
Studies both in vivo and in vitro have shown that substituted benzimidazoles inhibit the stimulation of acid secretion produced by dibutyryl cyclic AMP and histamine. Furthermore, the results differ from those produced by H2 antagonists and anticholinergic agents in that the inhibition is not competitive, and the site of action is intracellular and peripheral to that of dibutyryl cyclic AMP. To investigate the biochemical mechanism of action of substituted benzimidazoles, one such compound, H 149/94 (2-([2-(3-methyl)pyridyl-methyl]-sulphinyl)-5-methoxycarbonyl-6-methylbenzimidazol), has been tested either directly on an (H+ + K+)ATPase isolated from pig and human gastric mucosa or on the function of this enzyme in gastric glands isolated from rabbit and human gastric mucosa. (H+ + K+)ATPase, which has only been found at the secretory surface of the parietal cell, catalyses a one-to-one exchange of protons and potassium ions. It is possibly the proton pump within the gastric mucosa, and may thus be the terminal or one of the terminal steps of the acid secretory process. We show here that H 149/94 inhibits (H+ + K+)ATPase, which may explain its inhibitory action on acid secretion in vitro and in vivo. Because of the unique distribution and properties of the (H+ + K+)ATPase, the inhibitory action of H 149/94 on this enzyme may be a highly selective clinical means of suppressing the acid secretory process. 相似文献
17.
人工沸石:一种微波干法合成2-芳基取代苯并咪唑衍生物的高效催化剂 总被引:2,自引:0,他引:2
2-取代苯并咪唑是一类具有重要生物活性的化合物,尽管合成方法早在100多年前就有报道,但有关其新的合成方法至今仍不断有文献报道,最近有文献报道用PPA作缩合剂,微波辐照下合成了这类化合物.但这些方法总有一些不足,比如:污染严重、原料贵,步骤长、反应耗时、多有副反应发生、产率低等等,近年来,沸石的独特催化活性引起了人们的特别关注,同时,微波干法反应也正成为当前研窖的执占.因此裴们科研绸尝试将沸石等矿物裁体作为催化剂, 相似文献
18.
文中采用了双相滴定法中的亚甲基蓝逆滴定法分析了3种2-长碳链取代的苯并咪唑化合物的含量。并采用以往的薄层-非水滴定法对所得的结果进行了验证,证明本方法结果准确。 相似文献
19.
研究5-烷氧基-3,4-二卤-2(5H)-呋喃酮与2-苯并咪唑的Michael加成-消除反应过程中,发现发生的溶剂N,N-二甲基甲酰胺(DMF)在催化剂无水乙醇钠的作用下参与的串联反应.探讨了反应时间、催化剂用量、反应温度对反应的影响,合成了四个化合物(4a-4d).通过UV、IR、 1H NMR、13C NMR、MS、元素分析对4a-4d进行结构表征,提出并通过GC-MS验证了可能的反应机理. 相似文献
20.
作者采用微波辐射的方法,以2,5-二氯硝基苯和取代苯酚为原料,合成了2-芳氧基-5-氯硝基苯类化合物,该法反应速度快,收率高,副产物少,操作简便,对于微波在有机合成中的应用以及芳香族的亲核取代反应的研究均具有一定的价值。 相似文献