A partial elucidation of the gauge principle

The elucidation of the gauge principle “is the most pressing problem in current philosophy of physics” said Michael Redhead in 2003. This paper argues for two points that contribute to this elucidation in the context of Yang–Mills theories. (1) Yang–Mills theories, including quantum electrodynamics, form a class. They should be interpreted together. To focus on electrodynamics is potentially misleading. (2) The essential role of gauge and BRST symmetries is to provide a local field theory that can be quantized and would be equivalent to the quantization of the non-local reduced theory. If this is correct, the gauge symmetry is significant, not so much because it implies ontological consequences, but because it allows us to quantize theories that we would not be able to quantize otherwise. Thus, in the context of Yang–Mills theories, it is essentially a pragmatic principle. This does not seem to be the case for the gauge symmetry in general relativity.     

Did Einstein prove E=mc2?

Although Einstein's name is closely linked with the celebrated relation E=mc² between mass and energy, a critical examination of the more than half dozen “proofs” of this relation that Einstein produced over a span of forty years reveals that all these proofs suffer from mistakes. Einstein introduced unjustified assumptions, committed fatal errors in logic, or adopted low-speed, restrictive approximations. He never succeeded in producing a valid general proof applicable to a realistic system with arbitrarily large internal speeds. The first such general proof was produced by Max Laue in 1911 (for “closed” systems with a time-independent energy–momentum tensor) and it was generalized by Felix Klein in 1918 (for arbitrary time-dependent “closed” systems).     

Decision theory and information propagation in quantum physics

In recent papers, Zurek [(2005). Probabilities from entanglement, Born's rule p_k=|ψ_k|² from entanglement. Physical Review A, 71, 052105] has objected to the decision-theoretic approach of Deutsch [(1999) Quantum theory of probability and decisions. Proceedings of the Royal Society of London A, 455, 3129–3137] and Wallace [(2003). Everettian rationality: defending Deutsch's approach to probability in the Everett interpretation. Studies in History and Philosophy of Modern Physics, 34, 415–438] to deriving the Born rule for quantum probabilities on the grounds that it courts circularity. Deutsch and Wallace assume that the many worlds theory is true and that decoherence gives rise to a preferred basis. However, decoherence arguments use the reduced density matrix, which relies upon the partial trace and hence upon the Born rule for its validity. Using the Heisenberg picture and quantum Darwinism—the notion that classical information is quantum information that can proliferate in the environment pioneered in Ollivier et al. [(2004). Objective properties from subjective quantum states: Environment as a witness. Physical Review Letters, 93, 220401 and (2005). Environment as a witness: Selective proliferation of information and emergence of objectivity in a quantum universe. Physical Review A, 72, 042113]—I show that measurement interactions between two systems only create correlations between a specific set of commuting observables of system 1 and a specific set of commuting observables of system 2. This argument picks out a unique basis in which information flows in the correlations between those sets of commuting observables. I then derive the Born rule for both pure and mixed states and answer some other criticisms of the decision theoretic approach to quantum probability.     

Cytochemical localization of the K+ regulation interface between blood and brain

Summary Phosphatase activity identified with Na⁺–K⁺-ATPase was localized at the basal surface of cerebral cortical capillary endothelium by perfusion with a p-nitrophenyl phosphate-strontium medium. The relationship of this to the blood-brain barrier to K⁺ is discussed.     

Why the Afshar experiment does not refute complementarity

A modified version of Young's experiment by Shahriar Afshar demonstrates that, prior to what appears to be a “which-way” measurement, an interference pattern exists. Afshar has claimed that this result constitutes a violation of the Principle of Complementarity. This paper discusses the implications of this experiment and considers how Cramer's Transactional Interpretation easily accommodates the result. It is also shown that the Afshar experiment is analogous in key respects to a spin one-half particle prepared as “spin up along x”, subjected to a nondestructive confirmation of that preparation, and post-selected in a specific state of spin along z. The terminology “which-way” or “which-slit” is critiqued; it is argued that this usage by both Afshar and his critics is misleading and has contributed to confusion surrounding the interpretation of the experiment. Nevertheless, it is concluded that Bohr would have had no more problem accounting for the Afshar result than he would in accounting for the aforementioned pre- and post-selection spin experiment, in which the particle's preparation state is confirmed by a nondestructive measurement prior to post-selection. In addition, some new inferences about the interpretation of delayed choice experiments are drawn from the analysis.     

Modular localization and the holistic structure of causal quantum theory,a historical perspective

Recent insights into the conceptual structure of localization in QFT (modular localization) led to clarifications of old unsolved problems. The oldest one is the Einstein–Jordan conundrum which led Jordan in 1925 to the discovery of quantum field theory. This comparison of fluctuations in subsystems of heat bath systems (Einstein) with those resulting from the restriction of the QFT vacuum state to an open subvolume (Jordan) leads to a perfect analogy; the globally pure vacuum state becomes upon local restriction a strongly impure KMS state. This phenomenon of localization-caused thermal behavior as well as the vacuum-polarization clouds at the causal boundary of the localization region places localization in QFT into a sharp contrast with quantum mechanics and justifies the attribute “holstic”. In fact it positions the E–J Gedankenexperiment into the same conceptual category as the cosmological constant problem and the Unruh Gedankenexperiment. The holistic structure of QFT resulting from “modular localization” also leads to a revision of the conceptual origin of the crucial crossing property which entered particle theory at the time of the bootstrap S-matrix approach but suffered from incorrect use in the S-matrix settings of the dual model and string theory.The new holistic point of view, which strengthens the autonomous aspect of QFT, also comes with new messages for gauge theory by exposing the clash between Hilbert space structure and localization and presenting alternative solutions based on the use of stringlocal fields in Hilbert space. Among other things this leads to a reformulation of the Englert–Higgs symmetry breaking mechanism.     

Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals?

Formation of -linked Asp-Xaa peptide bonds – isoaspartyl (isoAsp) sites – arise in proteins via succinimide–linked deamidation of asparagine or dehydration of aspartate, reactions which represent a major source of spontaneous protein damage under physiological conditions. Accumulation of atypical isoaspartyl sites is minimized in vivo by the activity of protein L-isoaspartyl O–methyltransferase (PIMT), which regenerates a normal peptide bond. Loss of PIMT has harmful consequences, especially in neurons; thus, formation of isoAsp sites and their subsequent correction by PIMT is widely believed to constitute an important pathway of protein damage and repair. Recent evidence is mounting, however, that deamidation and isoaspartate formation may, in some instances, constitute a novel mechanism for intentional modification of protein structure. Herein we describe the mechanism of Asx rearrangement, summarize the evidence that PIMT serves an important repair function, and then focus on emerging evidence that deamidation and isoAsp formation may sometimes have a useful function.Received 16 October 2002; received after revision 11 December 2002; accepted 12 December 2002     

Explaining Leibniz equivalence as difference of non-inertial appearances: Dis-solution of the Hole Argument and physical individuation of point-events

“The last remnant of physical objectivity of space–time” is disclosed in the case of a continuous family of spatially non-compact models of general relativity (GR). The physical individuation of point-events is furnished by the autonomous degrees of freedom of the gravitational field (viz., the Dirac observables) which represent—as it were—the ontic part of the metric field. The physical role of the epistemic part (viz. the gauge variables) is likewise clarified as embodying the unavoidable non-inertial aspects of GR. At the end the philosophical import of the Hole Argument is substantially weakened and in fact the Argument itself dissolved, while a specific four-dimensional holistic and structuralist view of space–time (called point-structuralism) emerges, including elements common to the tradition of both substantivalism and relationism. The observables of our models undergo real temporal change: this gives new evidence to the fact that statements like the frozen-time character of evolution, as other ontological claims about GR, are model dependent.     

Subsystems and independence in relativistic microscopic physics

The analyzability of the universe into subsystems requires a concept of the “independence” of the subsystems, of which the relativistic quantum world supports many distinct notions which either coincide or are trivial in the classical setting. The multitude of such notions and the complex relations between them will only be adumbrated here. The emphasis of the discussion is placed upon the warrant for and the consequences of a particular notion of subsystem independence, which, it is proposed, should be viewed as primary and, it is argued, provides a reasonable framework within which to sensibly speak of relativistic quantum subsystems.     

Symmetry and asymmetry in electrodynamics from Rowland to Einstein

Halfway through the paper in which he laid down the foundations for the theory of special relativity, Einstein concludes that “the asymmetry mentioned in the Introduction … disappears.” Making asymmetry disappear has proved to be one of Einstein's many significant moves in his annus mirabilis of 1905. This elimination of asymmetry has led many commentators to claim that Einstein was motivated by either an aesthetic or an epistemic argument which gives priority to symmetry over asymmetry. Following closely the development of electrodynamics in the period from 1880 to 1905 and the usage of the related terms reciprocity and symmetry, we suggest a different way of understanding Einstein's motivation and the path he took. In contrast to the received view, we argue that Einstein responded to a debate in the literature on electrodynamics and that he was concerned neither with an aesthetic nor with an epistemic argument; rather, his reasoning was physical in the best sense, and most original. We will show that by providing a new perspective on the relation between electricity and magnetism, Einstein succeeded in bringing the discussion of symmetry in electrodynamics to an end.     

Quantum decoherence and the approach to equilibrium (II)

In a previous paper [Hemmo, M & Shenker, O (2003). Quantum decoherence and the approach to equilibrium I. Philosophy of Science, 70, 330–358] we discussed a recent proposal by Albert [(2000). Time and chance. Cambridge, MA: Harvard University Press. Chapter 7] to recover thermodynamics on a purely dynamical basis, using the quantum theory of the collapse of the quantum state of [Ghirardi, G, Rimini, A and Weber, T., (1986). Unified dynamics for microscopic and macroscopic systems. Physical Review, D 34, 470–479]. We proposed an alternative way to explain thermodynamics within no collapse interpretations of quantum mechanics. In this paper some difficulties faced by both approaches are discussed and solved: the spin echo experiments, and the problem of extremely light gases. In these contexts, we point out several ways in which the above quantum mechanical approaches as well as some other classical approaches to the foundations of statistical mechanics may be distinguished experimentally.     

Gauge theories and holisms

Those looking for holism in contemporary physics have focused their attention primarily on quantum entanglement. But some gauge theories arguably also manifest the related phenomenon of nonseparability. While the argument is strong for the classical gauge theory describing electromagnetic interactions with quantum “particles”, it fails in the case of general relativity even though that theory may also be formulated in terms of a connection on a principal fiber bundle. Anandan has highlighted the key difference in his analysis of a supposed gravitational analog to the Aharonov–Bohm effect. By contrast with electromagnetism in the original Aharonov–Bohm effect, gravitation is separable and exhibits no novel holism in this case. Whether the nonseparability of classical gauge theories of nongravitational interactions is associated with holism depends on what counts as the relevant part–whole relation. Loop representations of quantized gauge theories of nongravitational interactions suggest that these conclusions about holism and nonseparability may extend also to quantum theories of the associated fields.     

Ambiquitous behavior of rabbit liver lactate dehydrogenase

Summary Rabbit liver mitochondrial fraction shows lactate dehydrogenase activity. The enzyme can be released from particles by increasing the pH and the ionic strength of the medium. There is a narrow range of pH (6.8–7.4) and ionic strength (20–50 mM NaCl) in which the solubilization sharply increases. It has been shown that divalent anions (SO ₄ ^2– ) and cations (Mg²⁺, Ca²⁺) are highly effective specific solubilizing agents. NADH (1.5 mM) and ATP (1.0 mM) were effective in solubilizing 50% of the enzyme bound, whereas the same concentrations of the analogs NAD⁺ and ADP had little effect. Cytosolic lactate dehydrogenase bound to the mitochondrial fraction and a saturation of particles by enzyme was observed in all experiments performed. The in vitro binding requires a short period of incubation between the enzyme and particles and the binding is independent of the temperature in the 0–37°C range. Binding was prevented by 0.15 M NaCl. The bound enzyme is approximately 20% less active than the soluble one. The results described give support to the proposal that rabbit liver lactate dehydrogenase has an ambiquitous behavior, like other glycolytic enzymes, which have not a fixed intracellular localization.     

Formal and physical equivalence in two cases in contemporary quantum physics

The application of analytic continuation in quantum field theory (QFT) is juxtaposed to T-duality and mirror symmetry in string theory. Analytic continuation—a mathematical transformation that takes the time variable t to negative imaginary time—it—was initially used as a mathematical technique for solving perturbative Feynman diagrams, and was subsequently the basis for the Euclidean approaches within mainstream QFT (e.g., Wilsonian renormalization group methods, lattice gauge theories) and the Euclidean field theory program for rigorously constructing non-perturbative models of interacting QFTs. A crucial difference between theories related by duality transformations and those related by analytic continuation is that the former are judged to be physically equivalent while the latter are regarded as physically inequivalent. There are other similarities between the two cases that make comparing and contrasting them a useful exercise for clarifying the type of argument that is needed to support the conclusion that dual theories are physically equivalent. In particular, T-duality and analytic continuation in QFT share the criterion for predictive equivalence that two theories agree on the complete set of expectation values and the mass spectra and the criterion for formal equivalence that there is a “translation manual” between the physically significant algebras of observables and sets of states in the two theories. The analytic continuation case study illustrates how predictive and formal equivalence are compatible with physical inequivalence, but not in the manner of standard underdetermination cases. Arguments for the physical equivalence of dual theories must cite considerations beyond predictive and formal equivalence. The analytic continuation case study is an instance of the strategy of developing a physical theory by extending the formal or mathematical equivalence with another physical theory as far as possible. That this strategy has resulted in developments in pure mathematics as well as theoretical physics is another feature that this case study has in common with dualities in string theory.     

Experimental : The double standard in the quantum-information approach to the foundations of quantum theory

Among the alternatives of non-relativistic quantum mechanics (NRQM) there are those that give different predictions than quantum mechanics in yet-untested circumstances, while remaining compatible with current empirical findings. In order to test these predictions, one must isolate one's system from environmental induced decoherence, which, on the standard view of NRQM, is the dynamical mechanism that is responsible for the ‘apparent’ collapse in open quantum systems. But while recent advances in condensed-matter physics may lead in the near future to experimental setups that will allow one to test the two hypotheses, namely genuine collapse vs. decoherence, hence make progress toward a solution to the quantum measurement problem, those philosophers and physicists who are advocating an information-theoretic approach to the foundations of quantum mechanics are still unwilling to acknowledge the empirical character of the issue at stake. Here I argue that in doing so they are displaying an unwarranted double standard.     

A potent attractant of zoospores ofAphanomyces cochlioides isolated from its host,Spinacia oleracea

A highly potent attractant of zoospores ofAphanomyces cochlioides, a causal fungus of the root rot disease of spinach (Spinacia oleracea), was isolated from spinach roots, and its structure was determined by spectroscopic evidence and chemical synthesis as cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone,1). A chromosorb particle prepared by soaking in solution of1 showed a potent attracting activity toward the zoospores using concentrations of1 above 10^–9 or 10^–10 M.     

On the necessary truth of the laws of classical mechanics

The idealization of primitive mechanical experience is shown to lead to four mutually related formulations of classical mechanics based on connections, action at a distance, stresses, and collisions. For a given structure of spacetime and a given characterization of mechanical systems, fundamental laws (including Newton's law of acceleration and d’Alembert's principle) are derived from a few general principles regarding the comprehensibility of motion. Special emphasis is placed on the “secular principle,” according to which the evolution of a system at the relevant time scale should not depend on finer details of the applied forces.     

A remark on Fuchs’ Bayesian interpretation of quantum mechanics

Quantum mechanics is a theory whose foundations spark controversy to this day. Although many attempts to explain the underpinnings of the theory have been made, none has been unanimously accepted as satisfactory. Fuchs has recently claimed that the foundational issues can be resolved by interpreting quantum mechanics in the light of quantum information. The view proposed is that quantum mechanics should be interpreted along the lines of the subjective Bayesian approach to probability theory. The quantum state is not the physical state of a microscopic object. It is an epistemic state of an observer; it represents subjective degrees of belief about outcomes of measurements. The interpretation gives an elegant solution to the infamous measurement problem: measurement is nothing but Bayesian belief updating in a analogy to belief updating in a classical setting. In this paper, we analyze an argument that Fuchs gives in support of this latter claim. We suggest that the argument is not convincing since it rests on an ad hoc construction. We close with some remarks on the options left for Fuchs’ quantum Bayesian project.     

Classical fields and quantum time-evolution in the Aharonov–Bohm effect

I display, by explicit construction, an account of the Aharonov–Bohm effect that employs only locally operative electrodynamical field strengths. The terms in the account are the components of the magnetic field of the solenoid at the location of electron, and even though the total field vanishes there, the components do not. That such a construction can be carried out demonstrates at least that whatever virtues they have for understanding and constructing new field theories, gauge fields in general make no metaphysical demands, and commit us to no novel ontology. I reflect on the significance of this for our understanding of quantum time-evolution and conclude that we should think of quantized matter as interacting individually with the other matter in the systems of which it is a part.