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Specific binding of the transcription factor sigma-54 to promoter DNA. 总被引:11,自引:0,他引:11
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A mechanism for initiating RNA-dependent RNA polymerization 总被引:26,自引:0,他引:26
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A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. 总被引:15,自引:0,他引:15
A Finkelstein C F Kostrub J Li D P Chavez B Q Wang S M Fang J Greenblatt Z F Burton 《Nature》1992,355(6359):464-467
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Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein 总被引:12,自引:0,他引:12
Handa N Nureki O Kurimoto K Kim I Sakamoto H Shimura Y Muto Y Yokoyama S 《Nature》1999,398(6728):579-585
The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates alternative splicing of the transformer (tra) messenger RNA precursor by binding to the tra polypyrimidine tract during the sex-determination process. The crystal structure has now been determined at 2.6 A resolution of the complex formed between two tandemly arranged RNA-binding domains of the Sxl protein and a 12-nucleotide, single-stranded RNA derived from the tra polypyrimidine tract. The two RNA-binding domains have their beta-sheet platforms facing each other to form a V-shaped cleft. The RNA is characteristically extended and bound in this cleft, where the UGUUUUUUU sequence is specifically recognized by the protein. This structure offers the first insight, to our knowledge, into how a protein binds specifically to a cognate RNA without any intramolecular base-pairing. 相似文献
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RNA polymerase heterogeneity in Streptomyces coelicolor 总被引:5,自引:0,他引:5
Two forms of RNA polymerase holoenzyme have been identified in the filamentous differentiating bacterium Streptomyces coelicolor. They contain different species of sigma factor and are distinguishable by their ability to recognize different promoter classes. These and other holoenzyme forms may in part determine the selective expression of different gene sets in this morphologically-complex bacterium. 相似文献