共查询到20条相似文献,搜索用时 46 毫秒
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Tsukada Y Fang J Erdjument-Bromage H Warren ME Borchers CH Tempst P Zhang Y 《Nature》2006,439(7078):811-816
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Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression 总被引:1,自引:0,他引:1
Lan F Collins RE De Cegli R Alpatov R Horton JR Shi X Gozani O Cheng X Shi Y 《Nature》2007,448(7154):718-722
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Whyte WA Bilodeau S Orlando DA Hoke HA Frampton GM Foster CT Cowley SM Young RA 《Nature》2012,482(7384):221-225
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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 总被引:1,自引:0,他引:1
Cloos PA Christensen J Agger K Maiolica A Rappsilber J Antal T Hansen KH Helin K 《Nature》2006,442(7100):307-311
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p53 is regulated by the lysine demethylase LSD1 总被引:1,自引:0,他引:1
Huang J Sengupta R Espejo AB Lee MG Dorsey JA Richter M Opravil S Shiekhattar R Bedford MT Jenuwein T Berger SL 《Nature》2007,449(7158):105-108
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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development 总被引:2,自引:0,他引:2
Agger K Cloos PA Christensen J Pasini D Rose S Rappsilber J Issaeva I Canaani E Salcini AE Helin K 《Nature》2007,449(7163):731-734
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Greer EL Maures TJ Ucar D Hauswirth AG Mancini E Lim JP Benayoun BA Shi Y Brunet A 《Nature》2011,479(7373):365-371
Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants. 相似文献
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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription 总被引:4,自引:0,他引:4
Metzger E Wissmann M Yin N Müller JM Schneider R Peters AH Günther T Buettner R Schüle R 《Nature》2005,437(7057):436-439
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Peña PV Davrazou F Shi X Walter KL Verkhusha VV Gozani O Zhao R Kutateladze TG 《Nature》2006,442(7098):100-103
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Minutes after DNA damage, the variant histone H2AX is phosphorylated by protein kinases of the phosphoinositide kinase family, including ATM, ATR or DNA-PK. Phosphorylated (gamma)-H2AX-which recruits molecules that sense or signal the presence of DNA breaks, activating the response that leads to repair-is the earliest known marker of chromosomal DNA breakage. Here we identify a dynamic change in chromatin that promotes H2AX phosphorylation in mammalian cells. DNA breaks swiftly mobilize heterochromatin protein 1 (HP1)-beta (also called CBX1), a chromatin factor bound to histone H3 methylated on lysine 9 (H3K9me). Local changes in histone-tail modifications are not apparent. Instead, phosphorylation of HP1-beta on amino acid Thr 51 accompanies mobilization, releasing HP1-beta from chromatin by disrupting hydrogen bonds that fold its chromodomain around H3K9me. Inhibition of casein kinase 2 (CK2), an enzyme implicated in DNA damage sensing and repair, suppresses Thr 51 phosphorylation and HP1-beta mobilization in living cells. CK2 inhibition, or a constitutively chromatin-bound HP1-beta mutant, diminishes H2AX phosphorylation. Our findings reveal an unrecognized signalling cascade that helps to initiate the DNA damage response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code itself. 相似文献
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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response 总被引:1,自引:0,他引:1
L Kruidenier CW Chung Z Cheng J Liddle K Che G Joberty M Bantscheff C Bountra A Bridges H Diallo D Eberhard S Hutchinson E Jones R Katso M Leveridge PK Mander J Mosley C Ramirez-Molina P Rowland CJ Schofield RJ Sheppard JE Smith C Swales R Tanner P Thomas A Tumber G Drewes U Oppermann DJ Patel K Lee DM Wilson 《Nature》2012,488(7411):404-408