The activation mechanism of mammalian STE20-1ike kinase MST4

Under a research project funded by grants from the National Natural Science Foundation of China, Prof. Zhou Zhaocai, member of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Bi- ological Sciences, Chinese Academy of Sciences, and colleagues published their research findings in an arti- cle ＂Structure of the MST4 in complex with MO25 provides insights into its activation mechanism＂ in Structure （2013, 21（3）： 449- 61）.     

Cbx4 regulates tumor angiogenesis by sumoylating HIF-1α

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology, Prof. Chen Guoqiang, from the School of Medicine, Shanghai Jiao Tong University, and his colleagues published their research findings in an article ＂Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity＂ in Cancer Cell （2014, 25（1）： 118 131）.     

A long noncoding RNA controls human dendritic cells function

Under a research project supported by the National Natural Science Foundation of China （Grant Nos. 31390431 and 81230074） and the National Basic Research Program of China （Grant No. 2013CB530502）, Prof. Cao Xuetaoand his colleagues from the National I,aboratoryof Medical Immunology of the Institute of Immunology at the Second Military Medical University, Shanghai, published their research results entitled ＂The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation＂ in Science （2014, 311（6181）： 310 313）.     

Directly convert fibroblasts into hepatic stem cells

Under a research project supported by the National Natural Science Founda- tion of China, Prof. Hu Yiping, director of the Department of Cell Biology, Sec- ond Military Medical University and col- leagues published their research findings in an article ＂Reprogramming fibroblasts into hepatic stem cells by defined fac- tors＂ in Cell Stem Cell （2013, 13. 328-- 340）.     

A new insight about CFS breakage during chromosome condensation

Partially funded by the National Natural Science Foundation of China,Dr.Ying Songmin.a research scientist from the Institute of Respiratory Diseases of Zhejiang University published his research findings in an article entitled＂MUS81 promotes common fragile site（CFS）expression＂in Nature Cell Biology（2013,15（8）：1001—1007）.     

Thymine DNA glycosylase promotes Wnt/β-catenin signaling

With the support by the National Natural Science Foundation of China （Grant Nos. 31230044, 30930052 and 30900763） and the Ministry of Science and Technology of China （Grant No. 2010CB912100）, Prof. Li I.in＇s laboratory at the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, reported a novel function of thymine DNA glycosylase （TDG） as a coactivator in Wnt signaling through cooperating with CBP, which was published in Journal of Molecular Cell Biology （2014, 6： 231--239）.     

Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer

Under a research project funded by the National Natural Science Foundation of China.Prof.Sun Fenyong,a member of Shanghai Tenth People’s Hospital of Tongji University published his research findings in an article＂Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer＂in Hepatology（2013,58（3）：1011—1020）.     

Structural TET-mediated insight into 5mC oxidation

With the support by the National Natural Science Foundation of China （Grant Nos. 31270779 and 31030019） and National Basic Research Program of China （ Grant Nos. 2011CB965300 and 2009CB918600）, Prof. Xu Yanhui＇s laboratory at Fudan University Shanghai Cancer Center （FUSCC） and Institute of Biomedical Sciences （IBS）, Fudan University, reported the crystal structure of TET2-DNA complex, which was published in Cell （2013 , 155（7）： 1545 55）.     

Structural analysis and functional exploration of a leukemia-associated protein,IQCG

Supported financially by the National Natural Science Foundation of China, Prof. Chen Saijuan and Chen Zhu＇s laboratory at Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Jiao Tong University （SJTU） School of Medicine, published a research article in Nature Communications （2014, 5： 3811）, entitled ＂Functional and molecular features of the ealmodulin-interacting protein IQCG required for haematopoiesis in zebrafish＇.     

A novel inducible receptor on macrophages protects against endotoxin shock

With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China, Prof. Wang Hongyan＇s laboratory at the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, reported VEGFR-3 as a novel inducible receptor on macrophages to protect against endotoxin shock. This work was published as a cover story in Immunity （2014, 40（4）： 501--14）.     

Regulation of flowering time in perennial herbaceous plant

Under a research project funded by the National Natural Science Foundation of China,Dr.Wang Jiawei and his colleagues at the Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences published their research findings in an article entitled＂Molecular Basis of Age-Dependent Vernalization in Cardamine flexuosa＂in Science（2013,340：1097—1100）.     

A novel mechanism of cold-induced cardiovascular events

Supported by the National Natural Science Foundation of China,Prof.Zhang Yun and his doctorial student Dong Mei from Shandong University in collaboration with Prof.Cao Yihai from Karolinska Institute published an important research finding in an article entitled＂Cold-induced UCP1-dependent lipolysis promotes atherosclerotic plaque growth and instability＂in Cell Metabolism（2013,18（1）：118—129）.     

piRNAs degrade paternal mRNAs in late spermatogenesis

<正>Funded by the National Natural Science Foundation of China and the Ministry of Science and Techndogy of China,Prof.Liu Mofang's research group at Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences reported the novel function of piRNAs in targeting and degrading protein coding genes in mouse spermatids,which was published in Cell Res(2014,24(6):680—700).     

The promise of basal forebrain cholinergic neurons in stem cell-based therapy for Alzheimer's disease

<正>The research team led by Prof.Jing NaiHe(景乃禾)at the Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,reported the successful application of stem cell-based therapy in transgenic mouse models of Alzheimer's disease(AD).This finding was recently published in Stem Cell Reports(2015,5:776—790).     

Cbl-mediated neddylation promotes TGF-β signaling to attenuate leukemia development

Under a research project funded by the National Natural Science Foundation of China, the research group headed by Prof. Chen Yeguang at the School of Life Sciences, Tsinghua University, published their research findings as an article ＂e-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor＂ in Molecular Cell （2013, 49. 499 510）.     

Long noncoding RNAs go FAST,stem cells stay young—Distinct processing of lncRNAs contributes to non-conserved functions in stem cells

正With the support by the Chinese Academy of Sciences and the National Natural Science Foundation of China as well as Howard Hughes Medical Institute International Program,a research team led by Dr.Chen LingLing(陈玲玲)from the Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences,discovered that distinct processing of     

PIWI/piRNA activates spermiogenic mRNA translation

正Supported by the National Natural Science Foundation of China,a collaborative study led by Prof.Liu MoFang (刘默芳)from the Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Prof.Zhou Yu(周宇)from the College of Life Sciences,Institute of Advanced Studies,Wuhan University and Prof.Shi HuiJuan (施惠娟)from     

LincRNA-p21, a new player in the regulation of the Warburg effect

Recently, the research group led by Prof. Wu Mian and Prof. Mei Yide from University of Science and Technology of China has revealed a novel mechanism whereby lincRNA-p21 regulates the Warburg effect under hypoxic conditions. The paper entitled ＂Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect＂ has been published in the renowned international journal Molecular Cell （2014, 53： 88--100）.