A chromosome mutation affecting the number of nucleoli inXenopus borealis Parker

Résumé L'examen cytologique de la descendance de 2Xenopus borealis révéla 50% d'individus dotés de noyaux à 1 et 2 nucléoles (situation normale) et 50% à 1, 2 et 3 nucléoles. Le caryotype de ces derniers démontra la présence de 3 organisateurs nucléolaires, au lieu de 2, l'origine de l'élément supplémentaire relevant d'une translocation réciproque entre 4 et 7.

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Supported by a grant (No. 3.60.68) from the Fonds national suisse de la Recherche Scientifique and the George and Antoine Claraz donation.

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Unpublished research in this laboratory has shown thatXenopus laevis borealis (Parker) is a species on its own right and we propose to name itXenopus borealis (Parker).

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Material collected byFischberg andKobel, who express their gratitude to the Fisheries and Game Dept. of Kenya for permission to collect frogs of the genusXenopus.

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Acknowledgments. The authors wish to thank Mrs.J. Tymowska and MissE. Ackermann for their technical advice; they are grateful to Mr.J. Jackson, MissM. C. Payot, MissL. Ricard and Mr.P. Grutter for their assistance and useful help.     

Antibody against purified viper neurotoxin

Résumé L'anticorps contre la neurotoxine du venin deVipera palestinae est obtenu chez des lapins par immunisation de la neurotoxine purifiée liée à la cellulose carbométhylique.

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This work is part of a thesis submitted byN. Shaham to the

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This work is part of a thesis submitted byN. Shaham to the

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This work is part of a thesis submitted byN. Shaham to the

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This work is part of a thesis submitted byN. Shaham to the

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This work is part of a thesis submitted byN. Shaham to the     

Sur l'absence de biosynthèse des stérols et du squalène chez un coelentéré (anthozoaire), l'anémone de merCalliactis parasitica

Summary Sodium acetate I-¹⁴C has been injected to the sea anemoneCalliactis parasitica (coelenterate,anthozoa). Sterols and squalene were found unlabelled in this experiment. An analysis of the sterol mixture is reported.

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Nous remercionsMM. Cosson, Bardey etVarenne qui ont effectué les mesures de spectrométrie de masse sur un appareil AEI MS9, sous la direction du DrB. C. Das.

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Nous remercions le ProfesseurE. Lederer pour l'intérêt qu'il a porté à ce travail.

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Nous remercions la Station Biologique de Roscoff pour l'expédition de ces animaux.     

Sur l'absence de biosynthèse des stérols et du squalène chez un coelentéré (anthozoaire), l'anémone de merCalliactis parasitica

Summary Sodium acetate I-¹⁴C has been injected to the sea anemoneCalliactis parasitica (coelenterate,anthozoa). Sterols and squalene were found unlabelled in this experiment. An analysis of the sterol mixture is reported.

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Nous remercionsMM. Cosson, Bardey etVarenne qui ont effectué les mesures de spectrométrie de masse sur un appareil AEI MS9, sous la direction du DrB. C. Das.

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Nous remercions le ProfesseurE. Lederer pour l'intérêt qu'il a porté à ce travail.

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Nous remercions la Station Biologique de Roscoff pour l'expédition de ces animaux.     

Oxygen consumption of genetically obese rats

Zusammenfassung Der Sauerstoffverbrauch genetisch fettleibiger Ratten ist auffallend niedriger als derjenige von Normalratten (littermates), die nach Hypothalamusverletzung fettleibig wurden.

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J.Mayer, R. E.Russell, M. W.Bates and M. M.Dickie, Endocrinology56, 318 (1952).

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The author thanks Dr. E. B.Astwood for his continuing support and encouragement.     

Activation of virus production by DMSO in C. albicans experimentally infected with polyoma-DNA

Zusammenfassung Die Infektion von Schimmelpilzen,C. albicans, durch Polyomavirus mit isolierter Polyoma-DNS und die aktivierende Wirkung von DMSO werden beschrieben.

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Supported by a grant of the National Cancer Institute of Canada.

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The assistance of Mr. G.Kolompár and B.Bucz during these assays is gratefully acknowledged.     

Chemical constituents of the antibiotic fraction ofArnebia nobilis

Zusammenfassung Aus den Wurzeln vonArnebia nobilis wurden 4 antibiotisch wirksame Stoffe isoliert. Die Struktur von dreien wurde aufgeklärt.

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On deputation from the Chemistry Department, Lucknow University.

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To whom enquiries should be made. The isolation of shikonin monoacetate and,-dimethylacrylate fromLithosperm erythrorhizon, I.Morimoto, T.Kishi, S.Ikegana and Y.Hirata, Tetrahedron Lett.4737 (1965), has been brought to our notice since communicating this paper.

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Communication No. 1305 from the Central Drug Research Institute.     

Nachweis von Scilliglaucosidin in den Zwiebeln vonBowiea volubilis Harvey

Summary Hellebrigenin was converted to Scilliglaucosidin-19-ol and 3-Epi-Scilliglaucosidin-19-ol. This proves the correctness of the assumption ofStoll et al. ³ that the aldehydic group of Scilliglaucosidin is in position C-10.Comparison of a reduction product of Nabogenin, a substance isolated earlier from the bulbs ofBowiea volubilis Harvey, with Scilliglaucosidin-19-ol and 3-Epi-Scilliglaucosidin-19-ol showed its identity with the first named compound. This proves that the so called Nabogenin was a mixture consisting mainly of Scilliglaucosidin.

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8. Mitteilung über die Glykoside vonBowiea vocubilis Harvey und 162. Mitteilung über Glykoside und Aglykone.

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7. Mitt.:A. Katz, Helv. chim. Acta38, 1565 (1955).

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161. Mitt.:H. Kündig-Hegedüs undO. Schindler, Helv. chim. Acta39, 904 (1956).     

Terpenoid alkaloids fromMurraya koenigii Spreng. VII1 synthesis ofdl -O-Methylmahanine and related carbazoles

Zusammenfassung Die Synthese vondl-O-Methylmahanine wird beschrieben und damit die Struktur (IIa) für Mahanine bewiesen.

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Part VI.S. P. Kureel, R. S. Kapil andS. P. Popli, Chemy Ind. 1262 (1970).

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Communication No. 1640 from the Central Drug Research Institute, Lucknow.     

The effect of sulfhydryl reagents on cation binding by membrane fragments

Zusammenfassung Nachweis an Lebermikrosomen der Ratte, dass Sulfhydryl Reagenzienp-Chloromercuribenzoat (pCMB) undp-Chloromercuribenzol Sulfonat (pCMBS) die Bindung von Magnesium und Calcium ungefähr um 20% vermindern.

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I wish to thank Dr.George L. Ellman for several of the sulfhydryl reagents and for discussions relating to the present study. I also wish to thank Mr.Thian Vui Mark Lee for his capable assistance during the course of this investigation.     

Synthetic peptides related to caerulein1. Note 1

Riassunto Vengono descritte le proprietà di una serie di peptidi sintetici affini alla ceruleina e si discutono brevemente i rapporti fra attività e struttura.

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A. Anastasi, V. Erspamer andR. Endean, Experientia23, 699 (1967).

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This work was in part supported by grants from the Consiglio Nazionale delle Ricerche, Roma.     

Voacanga-Alkaloide IV. Struktur von Voacryptin und Voacristin

Summary Voacryptine is demonstrated to be 20-oxovoacangine. On reduction, it furnishes voacristine (20-hydroxyvoacangine) and 20-epi-voacristine.

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3. Mitt.U. Renner undD. A. Prins, Exper.15, 456 (1959).     

Effect of butyl alcohol inDatura innoxia Mill

Zusammenfassung Die Behandlung der Samen vonDatura innoxia Mill. mitn-Butylalkohol und Temperaturschock ergibt in der nächsten Generation Pflanzen, deren Samen einen höheren Alkaloidgehalt aufweisen. Das Hauptalkaloid ist Scopolamin (Hyoscin) mit einem Anteil von 50–70% am Gesamtalkaloidgehalt.

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The author is grateful to Dr. K.Ganapathi, Director, and Dr. C. K.Atal, Scientist of this Laboratory, for their interest in the work.Shri Het Singh, Dr. K. L.Dhar and MissSubash Kumari helped by analyzing the seeds which is duly acknowledged.     

Synthesis of Seselin and its hydroderivatives

Zusammenfassung Die Synthese des Naturstoffes Tetrahydroseselin aus der FruchtSeseli indicum wird beschrieben.

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Part X of a seriesCoumarins and Related Compounds. Part IX, A. K.Das Gupta, R. M.Chatterje and K. R.Das, J. chem. Soc. (C), (1969), 2618.     

Mass spectrometry in structural and stereochemical problems spegazzinine and spegazzinidine

Zusammenfassung Auf Grund von Protonresonanz und massenspektrometrischen Messungen werden die Strukturen III und VII für die Aspidosperma-Alkaloide Spegazzinidin und Spegazzinin vorgeschlagen.

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This paper represents part III. For preceding paper seeB. Gilbert, J. Ferreira, R. J. Owellen, C. E. Swanholm, H. Budzikiewicz, L. J. Durham, andC. Djerassi, Tetrahedron Letters,1962, 59.

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This paper represents Part VI in the La Plata seriesEstudios sobre Plantas; for paper V seeT. Nakano, C. Djerassi, R. A. Corral, andO. O. Orazi, J. org. Chem.26, 1184 (1961).     

Alkaloid studies XXIII isolation of four new aspidosperma alkaloids: Cylindrocarpine,refractine, pyrifoline,and pyrifolidine

Zusammenfassung Die Isolierung von vier neuenAspidosperma-Alkaloiden ergabCylindrocarpin (erstes N-Cinnamoyl-dihydroindolderivat) sowieRefractin, Pyrifolin undPyrifolidin (alles N-Acetyl-dihydroindole), die alle vier eine Methoxylgruppe im Dihydroindolsystem besitzen.

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Postdoctorate research fellow 1958–1959 (Wayne State University); 1959–1960 (Stanford University).

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Paper XXII,J. S. E. Holker, M. Cais, F. A. Hochstein undC. Djerassi, J. org. Chem.24, 314 (1959).     

Über die Alkaloide vonRauwolfia ligustrina R. & S. Raugustin,ein neues reserpinähnliches Alkaloid

Summary Twenty-one alkaloids have been identified from the root ofRauwolfia ligustrina R. & S. The more important ones are reserpine, pseudoreserpine and raugustine, a new base which is isomer to pseudoreserpine. The structure of the latter compound is discussed.

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Mitteilung über Rauwolfia-Alkaloide

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Mitteilung sieheC. F. Huebner undE. Schlittler, J. Amer. chem. Soc.79, 250 (1957).     

Bazzanenol,a new sesquiterpene alcohol having a skeleton of Bicyclo[5.3.1] undecane system from hepaticae,Bazzania pompeana (Lac.) Mitt

Zusammenfassung Isolierung und Strukturaufklärung eines neuen Sesquiterpenalkohols ausBazzania pompeana (Lac.) Mitt.

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Studies on chemical constituents from Hepaticae, Part III: S.Hayashi, A.Matsuo and T.Matsuura, Tetrahedron Letters,1969, 1599 and ref.² are regarded as Part I and II.     

Zinc sulphate induces sterility in the cotton leafwormSpodoptera littoralis boisduval

Zusammenfassung Eine subletale Konzentration von 0,3% Zinksulfat im Larven-Nährmedium der BaumwolleuleSpodoptera littoralis ergibt morphologisch und im Verhalten normale Falter, die jedoch vollkommen steril sind und zudem eine stark reduzierte Fekundität aufweisen.

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I am indebted to Mrs.El-Sharaby for her help during this work.     

Über Peptidsynthesen. C-terminale Teilsequenzen des Eledoisins und eledoisinanaloger Verbindungen

Summary A series of synthetic Eledoisin and Eledoisin-related subunits are described. The biological activities of the peptides are discussed.

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Über Peptidsynthesen XXIII. 2. Mitt. über Eledoisin und Eledoisinanaloga. 1. Mitt. siche⁹.

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B. Camerino, G. de Caro, R. A. Boissonnas, Ed. Sandrin undE. Stürmer, Exper.19, 339 (1963).