共查询到20条相似文献,搜索用时 46 毫秒
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Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators 总被引:11,自引:0,他引:11
Demarest SJ Martinez-Yamout M Chung J Chen H Xu W Dyson HJ Evans RM Wright PE 《Nature》2002,415(6871):549-553
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CBP-independent activation of CREM and CREB by the LIM-only protein ACT 总被引:29,自引:0,他引:29
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CREBBP mutations in relapsed acute lymphoblastic leukaemia 总被引:2,自引:0,他引:2
Mullighan CG Zhang J Kasper LH Lerach S Payne-Turner D Phillips LA Heatley SL Holmfeldt L Collins-Underwood JR Ma J Buetow KH Pui CH Baker SD Brindle PK Downing JR 《Nature》2011,471(7337):235-239
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Bone and haematopoietic defects in mice lacking c-fos. 总被引:26,自引:0,他引:26
Z Q Wang C Ovitt A E Grigoriadis U M?hle-Steinlein U Rüther E F Wagner 《Nature》1992,360(6406):741-745
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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase 总被引:13,自引:0,他引:13
Cbl is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface. The evolutionarily conserved amino-terminal region of Cbl (Cbl-N) binds to phosphorylated tyrosine residues and has cell-transforming activity. Point mutations in Cbl that disrupt its recognition of phosphotyrosine also interfere with its negative regulatory function and, in the case of v-cbl, with its oncogenic potential. In T cells, Cbl-N binds to the tyrosine-phosphorylated inhibitory site of the protein tyrosine kinase ZAP-70. Here we describe the crystal structure of Cbl-N, both alone and in complex with a phosphopeptide that represents its binding site in ZAP-70. The structures show that Cbl-N is composed of three interacting domains: a four-helix bundle (4H), an EF-hand calcium-binding domain, and a divergent SH2 domain that was not recognizable from the amino-acid sequence of the protein. The calcium-bound EF hand wedges between the 4H and SH2 domains and roughly determines their relative orientation. In the ligand-occupied structure, the 4H domain packs against the SH2 domain and completes its phosphotyrosine-recognition pocket. Disruption of this binding to ZAP-70 as a result of structure-based mutations in the 4H, EF-hand and SH2 domains confirms that the three domains together form an integrated phosphoprotein-recognition module. 相似文献
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Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. 总被引:30,自引:0,他引:30
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CREB is activated in EPO induced HEL cells 总被引:1,自引:0,他引:1
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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells 总被引:119,自引:0,他引:119
Park IK Qian D Kiel M Becker MW Pihalja M Weissman IL Morrison SJ Clarke MF 《Nature》2003,423(6937):302-305