共查询到20条相似文献,搜索用时 78 毫秒
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Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) 总被引:4,自引:0,他引:4
R. Kakkar R. V. S. Raju R. K. Sharma 《Cellular and molecular life sciences : CMLS》1999,55(8-9):1164-1186
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Junhua Zhao Albino Bacolla Guliang Wang Karen M. Vasquez 《Cellular and molecular life sciences : CMLS》2010,67(1):43-62
Repetitive DNA motifs are abundant in the genomes of various species and have the capacity to adopt non-canonical (i.e., non-B)
DNA structures. Several non-B DNA structures, including cruciforms, slipped structures, triplexes, G-quadruplexes, and Z-DNA,
have been shown to cause mutations, such as deletions, expansions, and translocations in both prokaryotes and eukaryotes.
Their distributions in genomes are not random and often co-localize with sites of chromosomal breakage associated with genetic
diseases. Current genome-wide sequence analyses suggest that the genomic instabilities induced by non-B DNA structure-forming
sequences not only result in predisposition to disease, but also contribute to rapid evolutionary changes, particularly in
genes associated with development and regulatory functions. In this review, we describe the occurrence of non-B DNA-forming
sequences in various species, the classes of genes enriched in non-B DNA-forming sequences, and recent mechanistic studies
on DNA structure-induced genomic instability to highlight their importance in genomes. 相似文献
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M. Fontecave 《Cellular and molecular life sciences : CMLS》1998,54(7):684-695
Ribonucleotide reductases (RNRs) catalyse the reduction of ribonucleotides to deoxyribonucleotides. They play a pivotal role
in the regulation of DNA synthesis and are targets for antiproliferative drugs. Ribonucleotide reductases are unique enzymes
in that they all require a protein radical for activity. Class I nonheme iron RNRs (mammals, plants, Escherichia coli) use a tyrosyl/cysteinyl radical pair, class II adenosylcobalamin RNRs (prokaryotes, archaea) a cysteinyl radical, class
III iron-sulphur RNRs (facultative anaerobes) a glycyl radical. Here we describe the reactivity of these radicals with respect
to the natural ribonucleotide substrates as well as to a variety of enzyme inhibitors, radical scavengers, nitric oxide, superoxide
radicals and substrate analogues.
Received 3 December 1997; received after revision 26 February 1998; accepted 27 February 1998 相似文献
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DNA methylation and the regulation of gene transcription 总被引:28,自引:0,他引:28
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The evolutionary conservation of eukaryotic gene transcription 总被引:1,自引:0,他引:1
M Schena 《Experientia》1989,45(10):972-983
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The short proline-rich antibacterial peptide family 总被引:16,自引:0,他引:16
Otvos L 《Cellular and molecular life sciences : CMLS》2002,59(7):1138-1150
From the many peptide families that are induced upon bacterial infection and can be isolated from all classes of animals,
the short, proline-rich antibacterial peptides enjoy particular interest. These molecules were shown to inactivate an intracellular
biopolymer in bacteria without destroying or remaining attached to the bacterial cell membrane, and as such emerged as viable
candidates for the treatment of mammalian infections. These peptides were originally isolated from insects, they kill mostly
Gram-negative bacteria with high efficiency and they show structural similarities with longer insect- and mammal-derived antimicrobial
peptides. However, while the distant relatives appear to carry multiple functional domains, apidaecin, drosocin, formaecin
and pyrrhocoricin consist of only minimal determinants needed to penetrate across the cell membrane and bind to the target
biopolymer. These peptides appear to inhibit metabolic processes, such as protein synthesis or chaperone-assisted protein
folding. Pyrrhocoricin derivatives protect mice from experimental infections in vivo, suggesting the utility of modified analogs
in the clinical setting. Sequence variations of the target protein at the peptide-binding site may allow the development of
new peptide variants that kill currently unresponsive strains or species.
Received 12 December 2001; received after revision 11 February 2002; accepted 19 February 2002 相似文献
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RNA-mediated gene silencing 总被引:21,自引:0,他引:21
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K. Sandman S. L. Pereira J. N. Reeve 《Cellular and molecular life sciences : CMLS》1998,54(12):1350-1364
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Functions of the MDM2 oncoprotein 总被引:34,自引:1,他引:33