A new synthetic method of coumestan derivatives

Zusammenfassung Die Synthese von 7-Hydroxy-5,6-dimethoxybenzofurano[3,2:3,4]coumarin aus 7,2-Dihydroxy-oder 7-Benzyloxy-2-hydroxy-4,5-dimethoxyisoflavon wird beschrieben.     

The syntheses of axillarin and its related compounds

Zusammenfassung Axillarin (5, 7, 3, 4-Tetrahydroxy-3,6-dimethoxyflavon). 5,3,4-Trihydroxy-3,6,7-trimethoxyflavon und 5,7,3,4-Tetrahydroxy-3,8-dimethoxyflavon wurden synthetisiert.     

The effect of cyclic N-2-O-dibutyryl-adenosine-3′, 5′-monophosphate on neuromuscular transmission and concentration of glycogen in the isolated phrenic nerve-diaphragm preparation of the rat

Résumé Le dérivé dibutyrique du 3, 5-AMP cyclique potentialise les contractions du diaphragme provoquées par stimulation électrique indirecte, alors que l'application du 3,5-AMP cyclique n'a pas un tel effet. D'autre part, ce dérivé diminue le taux de glycogène du diaphragme, ce qui n'est pas le cas pour le 3,5-AMP cyclique.     

Synthesis of dinucleoside phosphates by reaction of 5′-chloro-5′-deoxynucleosides with nucleotide anions

Zusammenfassung Uridylyl-(3–5)-adenosin und Uridylyl-(3-5)-ionosin wurden durch Umsetzung eines passenden 5-chloro-5-deoxy-2, 3-O-isopropylidene-Nukleosids mit Uridin-3-phosphat synthetisiert.     

Cyclic AMP and cyclic GMP in rats paw edema by prostaglandins

Summary Experimental results indicate that rat's paw oedema development by PGs is inhibited by 35 AMP and increased by 35 GMP. This research confirms the opposite effect to that of cyclic nucleotides. The respective behaviour of 35 AMP and 35GMP in their primary oedema-induced activity is discussed.We gratefully acknowledge the technical assistence of Mr.Sauro Pellegrini.     

Total synthesis of orellinine,a minor toxic component of the fungusCortinarius orellanus fries

Summary The 3,3,4,4-tetrahydroxy-2,2-bipyridyl-N-oxide has been synthesized by dealkylation of the corresponding tetramethyl derivative. The chemical properties of this compound are identical to those reported for the minor fungal toxin ofCortinarius orellanus, orellinine.This work is part of the Tesi di Laurea of Miss Cinzia Pierucci.     

The synthesis of a natural dinucleoside phosphate derivative with the aid of a purine cyclonucleoside

Zusammenfassung Die Behandlung von 8-5-Anhydro-8-mercapto-2-o-mesylguanosin mit (1,2 Äquivalent) Tributylammonium-uridylat in siedendem DMF lieferte das Dinucleosidphosphat Uridyl-(3-5)-8-mercapto-2-o-mesylguanosin. Weitere Behandlung mit Raney Ni führte zum Uridyl-(3-5)-2-o-mesylguanosin.     

Fever produced in rabbits by N6, O2′-dibutyryl adenosine 3′, 5′-cyclic monophosphate

Zusammenfassung Die Injektion von N⁶-2-O-Dibutyryl-adenosin-3 5-monophosphat in den lateralen Hirnventrikel von Kaninchen führt zu einer langanhaltenden Fieberreaktion, was vermuten lässt, dass zyklisches Adenosin-35-monophosphat als weiterer Mediator in der Genese des Fiebers fungiert.     

Microbiological transformation of biflavone

Summary Incubation of 5,5-7,7-tetramethoxy-8,8-biflavone withAspergillus niger results in the formation of 4,4-dihydroxy-5,5-7,7-tetramethoxy-8,8-biflavan.Part of this work was done at Allahabad University, Chemical Laboratories.     

Die Induktion lysogener Bakterien durch Nitrosamide

Summary N, N-dinitroso-N, N-dimethyloxamide and N, N-dinitroso-N, N-dimethylterephtal acid amide, both mutagenic for yeast cells, induce phage production by lysogenicEscherichia coli K12 () cells.     

Polyhydroxylated metabolites oftrans-stilbene in the rat

Zusammenfassung Nach Eingabe vontrans-Stilben bei Ratten wurden die grössten Mengen im Harn als 3,4,4-Trihydroxystilben, 3,4,4-Trihydroxybibenzyl und 3,3, 4,4-Tetrahydroxybibenzyl nachgewiesen. Die Bibenzylderivate werden nachscheinlich nach Ausscheidung in der Galle von Darmbakterien metabolisiert.     

A study of the mechanism of polymyxin M inactivation

.I.NH₄OH , N N - - ,-. , .     

Inhibition of the growth of cariogenic bacteria in vitro by plant falvanones

Phytoalexins, defensive compounds produced by plants against microbial infections, were purified fromSophora exigua (Leguminosae) and their growth inhibitory effects on oral cariogenic bacteria were determined in vitro. Among three isolated compounds, 5,7,2,4-tetrahydroxy-8-lavandulylflavanone completely inhibited the growth of oral bacteria including primary cariogenic mutans streptococci, other oral streptococci, actinomycetes, and lactobacilli, at concentrations of 1.56 to 6.25 g/ml.     

Enhancement of anaphylaxis of isolated smooth muscle by adenosine phosphates and inhibition of anaphylactic mechanisms by adenosine-3′,5′-cyclic monophosphate

Zusammenfassung Zyklisches 3,5-Adenosinmonophosphat hindert in vitro die Anaphylaxis des glatten Muskels vom Meerschweinchenuterus, während Adenosin und Adenosin-5-Monophosphat die anaphylaktische Reaktion erhöhen.     

Iso-cannabispiran,a new spiro compound isolated from Panamenian variant ofCannabis sativa L.

Summary An acidic fraction of Panamenian variant ofCannabis sativa L., afforded upon repeated chromatography a new non-cannabinoid phenol {5-hydroxy-7-methoxy spiro-(cyclohexane-1, 1-indan)-4-one}Ia, named iso-cannabispiran.Acknowledgment. Supported in part by NIDA contract No. 271-78-3527 and by the Research Institute of Pharmaceutical Sciences.     

Zur Synthese des Batrachotoxinins: Synthese von 3β-Acetoxy-16β, 20β-dihydroxy-4′-methyl-18-nor-5β, 14β-pregnano[13,14-f]hexahydro-1′,4'-oxazepin-3′-on(20a)

Summary The synthesis of 3-acetoxy-16, 20-dihydroxy-4-methyl-18-nor-5, 14-pregnano[13,14-f]hexahydro-1, 4-oxazepin-3-one (20a) is described.     

A new synthesis of dehydromunduserone

Zusammenfassung Eine einfache Synthese von Dehydromunduseron aus 7,2,4,5-Tetramethoxy-isoflavon wird beschrieben.     

Occurrence of 3-epi-22-deoxy-20-hydroxyecdysone and its phosphoric ester in diapause eggs of the silkworm,Bombyx mori

Ecdysteroids in diapause eggs of the silkworm,Bombyx mori, were analyzed using high-performance liquid chromatography (HPLC) combined with radioimmunoassay (RIA). A relatively large amount of an unidentified free ecdysteroid and its phosphoric ester (conjugated form) were detected. These two compounds were isolated by a combination of column chromatography on silicic acid, thin-layer chromatography (TLC), and HPLC using a reverse-phase (RP) column. The purified compounds were identified as 3-epi-22-deoxy-20-hydroxyecdysone (22d20E) and 3-epi-22-deoxy-20-hydroxyecdysone 2-phosphate (22d20E2P) by means of mass spectrometry and nuclear magnetic resonance spectroscopy. to our knowledge, this is the first report of 22d20E and 22d20E2P.     

Magnug reflexex of the chest musculature in man

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