The inferences of common causes reduced to common origins

This paper advocates the reduction of the inference of common cause to that of common origins. It distinguishes and subjects to critical analysis thirteen interpretations of “the inference of common cause” whose conclusions do not follow from their assumptions. Instead, I introduce six types of inferences of common origins of information signals from their receivers to reduce, in the sense of supersede and replace, the thirteen inferences of common causes. I show how the paradigmatic examples of inferences of common cause, as well as a broader scope of inferences in the historical sciences, are better explained by inferences of origins.Inferences of origins from information rich coherences between receivers of information signals both fit more closely and explain better the range of examples that have traditionally been associated with inferences of common causes, as well as a broader scope of examples from the historical sciences. Shannon's concept of information as reduction in uncertainty, rather than physicalist concepts of information that relate it to entropy or waves, simplifies the inferences, preempts objections, and avoids the underdetermination of conclusions that challenge models of inferences of common causes.In the second part of the paper I model inferences of common origins from information preserved in their receivers. I distinguish information poor inferences that there were some common origins of receivers from the information richer inferences of ranges of possible common origins and the information transmission channels by which they transmitted signals to receivers. Lastly and most information rich, I distinguish the inference of the defining properties of common origins. The information transmission model from origins to receivers allows the reconceptualization of the concepts of "independence" as absence of intersections between information channels and "reliability" as the preservation of information from origins in receivers. Finally, I show how inferences of origins form the epistemic basis of the historical sciences.     

Demonstration of Yersinia pseudotuberculosis in in cultivated soils]

The bacteriological analysis of 37 pools of cultivated soils collected in a limited area in the Parisian district permits the isolation of 14 strains of Y. pseudotuberculosis: 9 strains are of serotype II, 3 of serotype I, 1 of serotype III, and of serotype IV. This diversity contrasts with the prevalence of serotype I in infections of man and animals and the scarcity of type III and IV in these species. The abundance of our isolates is in favour of a large distribution of the germ in this substratum, which can be considered as a potential contamination source.     

Reflections on the preservation of recent scientific heritage in dispersed university collections

The bulk of the significant recent scientific heritage of universities is not to be found in accredited science museums or collections employed in research. Rather it is located in a wide variety of more informal collections, assemblages and accumulations. The selection and documentation of such materials is very often unsystematic and many of them are vulnerable to changes of staff, relocation and, above all, shortage of space. Following a survey of views on the values of the recent material heritage of the sciences, I consider the many advantages—for teaching, engagement with wider communities, enhancement of institutional identity and work experience, celebration of scientific achievements, study of the recent history of the practices and fruits of the sciences, etc.—of “multi-site museums” formed through the coordination of such varied and scattered collections. I go on to reflect on ways in which the preservation and display of scientific heritage in dispersed collections may be enhanced and protected through institutional recognition and through provision of guidance and assistance in selection, documentation and digitisation, preservation and conservation, and display. The importance of adequate documentation of the contexts of production and use of objects is stressed, as are the benefits that can result from involvement of student “taskforces” and heritage-concerned scientists.     

The discovery of antidepressants: a winding path

Modern treatment of mental depression started with the availability of monoamine oxidase (MAO) inhibitors and tricyclic antidepressants. These drugs also contributed to the early development of psychopharmacology. Attempts to improve the anti-tuberculous action of the hydrazine derivative isoniazid by developing derivatives thereof led to the synthesis of iproniazid. Its introduction as the first modern antidepressant was based on three unexpected actions of the drug: MAO-inhibition, 'reversal' of reserpine-induced sedation, and the presence of psychostimulation as a clinical side effect in man. However, the initial success of iproniazid and other MAO inhibitors, hydrazides and non-hydrazides, was curtailed by the occurrence of undesirable side effects such as potentiation of the blood-pressure elevating action of food amines. The tricyclic antidepressants were a development of the class of antihistamines, one of which, chlorpromazine, showed neuroleptic activity. A congener of this compound, imipramine, was discovered by clinical observation to have unexpected antidepressant effects. The clinical success of this drug (which is still in use) led to the development of a successful series of other tricyclic and non-tricyclic antidepressants. Progress in the elucidation of possible mechanisms of the action of the tricyclic compounds has helped this development. Recent advances in basic research have also induced a revival of MAO-inhibitors since, due to the discovery of MAO-subtypes, inhibitors with higher specificity and fewer undesirable side effects are now available.     

Production of pharmaceutical proteins in milk

There is every reason to expect that it will be possible within the next few years to begin to use farm animals to produce large quantities of some of the human proteins that are needed for the treatment of disease. Revolutionary new opportunities for the production of novel proteins in milk have been created by the development of methods for gene transfer. Exploitation of these opportunities depends upon selection and cloning of milk protein genes and identification of the sequences that govern tissue specific hormonally induced expression in the mammary gland. Studies with three genes, ovine beta-lactoglobulin, rat beta-casein and whey acidic protein of rat and mouse, suggest that they may all meet this requirement. Fragments of the ovine beta-lactoglobulin, murine whey acidic protein and rabbit beta-casein genes have directed production of novel proteins in the milk of transgenic mice, sheep, rabbits and pigs. The proteins were biologically active and usually co-migrated with authentic proteins. In early experiments, protein concentration was low, but our recent observations suggest that fusion genes containing genomic clones direct production of concentrations of protein that are suitable for commercial exploitation. In the longer term, two approaches may offer the potential of more reliable expression. Control elements capable of directing expression that is independent of site of insertion of the gene, but dependent on the number of copies of the gene, have been identified for a small number of genes. The availability of such elements for the milk protein genes would increase the reliability of gene expression considerably. Alternatively, targeted mutation of genes may allow the insertion of coding sequences within an existing gene so avoiding position effects.     

Produktion von Acetylmethylkarbinol durch Aktinomyzeten

Summary The production of acetylmethylcarbinol by various strains of actinomycetes was established. The biosynthesis of acetylmethylcarbinol depends largely on the composition of the fermentation medium and on the presence of arsenite, which regulates the metabolism of pyruvic acid. In the case ofStreptomyces aureofaciens the stimulating effect of phosphate on the production of acetylmethylcarbinol gives a partial explanation of the well-known negative effect of phosphate on the biosynthesis of chlortetracycline.     

The Transformation of Aristotle's Mechanical Questions: A Bridge Between the Italian Renaissance Architects and Galileo's First New Science

The reception process of Aristotle's Mechanical Questions during the early modern period began with the publication of the corpus aristotelicum between 1495 and 1498. Between 1581 and 1627, two of the thirty-five arguments discussed in the text, namely Question XIV concerning the resistance to fracture and Question XVI concerning the deformation of objects such as timbers, became central to the work of the commentators. The commentaries of Bernardino Baldi (1581–1582), Giovanni de Benedetti (1585), Giuseppe Biancani (1615) and Giovanni di Guevara (1627) gradually approached the doctrine of proportions of the Renaissance architects, some aspects of which deal with the strength of materials according to the Vitruvian conception of scalar building. These aspects of the doctrine of proportions were integrated into the Aristotelian arguments so that a theory of linear proportionality concerned with the strength of materials could be formulated. This very first theory of strength of materials is the theory to which Galileo critically referred in his Discorsi where he published his own theory of strength of materials. Economic and military constraints are determined as the fundamental reasons for the commentators’ commitment to developing a theory of strength of materials that later linked Galileo's work to the practical knowledge of the architects and machine-builders of his time.     

Idealisation,genetic explanations and political behaviours: Notes on the anti-reductionist critique of genopolitics

The rapid development of genetic research, determined, among others, by the requirements of The Human Genome Project, and a gradual reorientation in the perception of the role of nature and culture in the process of shaping complex networks of human relations by some political scientists, result in the increasing application of genetic data and methods in research regarding political behaviours. One of the key philosophical objections against the studies of the genetic foundations of political behaviours is that of excessive reductionism. This is supposed to manifest itself in the inadequate selection of the level of analysis for the explained phenomenon, the incompleteness of explanations and their low utility. My findings show that this objection is not sufficiently supported by contemporary science. Both studies using classical behavioural genetic methodologies and studies using DNA-based methods show that genes most likely play a role in political behaviours. Emphasising the significance of genetic influences in the midst of multiple extra-genetic interactions generates highly idealised explanations. Using the conceptual apparatus of the deformational concept of culture, I have demonstrated that the omission of a number of important extra-genetic influences by researchers is a consequence of focusing on specific causal patterns. This omission, however, does not entail negating the influence of non-genetic factors and, importantly, it may not have to be permanent. Following this approach, if correct, the reductionism of research into the genetic foundations of political behaviours is a standard cognitive procedure applied in science.     

Physical,Human and Divine attraction in the life and thought of George Cheyne

This paper is a study of the mental environment of the Newtonian conception of attraction in the case of George Cheyne, M.D. (1671–1743), physician of the early 18th century and author of a number of popular medical works. It traces the growth of his notions of a spiritual attraction between God and his creatures and between the creatures themselves, and the relation of these ideas both to his use of the Newtonian model of short-range attraction, and to his conception of the creatures as reflections of the divine essence. The paper contends that the development of these aspects of Cheyne's thought harmonizes with the changing pattern of his life, and that this harmony is expressed by his general technique of reasoning by analogy between the various spheres of experience.