Changes in the lumen of coronary vessels under oligemic hypotension

Conclusions The decrease of circulating blood volume, resulting in oligemic hypotension, may evoke in anaesthetized cat the active constrictory coronary vessel responses of 2 types, one occuring immediately after start of the hypotension and the other having a significantly prolonged latency.

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, , , , ( 4 ), ( 45 ).

     

The peculiarities of capacitance vessel reflex responses

Conclusion Changes of the vessel capacity resulted from the pressor synocarotid reflexes, intestinal chemoreflexes and reflexes from the right atrium or ventricle and electric stimulation of the somatic nerve afferents can be either similarly or differently directed as compared with the responses of the resistance vessels.

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, , , .

     

Artificial lung ventilation during diaphragmatic paralysis

ÿe , CO₂ . CO₂ ÿe . , ÿe , .     

The antifertility action of α-chlorohydrin: metabolism by rat and boar sperm

Summary The male antifertility agent -chlorohydrin (I) is metabolized by rat and boar sperm to -chloroactaldehyde (III), -chlorolactate (IV) and Cl^– and not to the proposed active metabolite, -chlorohydrin-1-phosphate (III). It is proposed that -chlorolactaldehyde is produced intracellularly by a specific enzyme and that this is the metabolite responsible for the species-specific antifertility activity of -chlorohydrin.This work was supported by The National Health and Medical Research Council of Australia.     

Chromosomes and giemsa-bands of the Idaho spotted ground squirrel,Spermophilus brunneus (Howell)

-Spermophilus brunneus . , 13 18 ,S. brunneus S. townsendii mollis (2n=38) , , ; ;S. brunneus . S. brunneus , Spermophilus.

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Supported by National Science Foundation Grants No. GB32114X and No. GB 29131X, and the Sprague Foundation. We thankD. Pozin for technical assistance.     

IdentifyingY chromosome in interphase nuclei of the human brain

. . . -- , - .     

Gamma-aminobutyric acid uptake by rat kidney brush-border membrane vesicles

Summary Brush-border membrane vesicles (BBMV) from rat kidney cortex possessed two uptake systems for -aminobutyric acid (GABA), a high affinity system (Km=10.9 M) and a low affinity system (Km=1203 M). Both uptake systems were inhibited by p-hydroxymercuribenzoic acid and ouabain, and by the action of neuraminidase, whereas the GABA analogs nipecotic acid, -alanine, 2,4-diaminobutyric acid and 4,5,6,7-tetrahydroisoxazolo-[4,5c]-pyridin-3-ol had no effect on the GABA uptake activity. The BBMW uptake systems were clearly different from the GABA transport systems present in brain tissue.     

DNA synthesis and mitoses in atrial myocytes of rats with aortal stenosis

, . 2- , 1,60 ±0,59% , 0,96 ± 0,44% — . ë . , ³- .     

Proteins of venezuelan equine encephalomyelitis virions

. : (. . 59,000–61,000 ), (34,000–38,000) (15,000–18,000).     

Specific enhancement of the cytotoxic titre with regard to complement source and cytotoxicity test systems

Zusammenfassung Es wird gezeigt, dass im Cytotoxizitätstest mit Mäuselymphocyten der cytotoxische Titer durch Neuraminidasevorbehandlung stark gesteigert werden kann, falls Kaninchenserum als Komplement verwendet wird. Durch trypsin- oder Ficin-Vorbehandlung wird nur eine schwache Steigerung erzielt. Im Gegensatz zum Cytotoxizitätstest mit unbehandelten Lymphozyten wird der stärkste Titeranstigg bei der one step-Methode beobachtet. Um die spezifische Titererhöhung mit Kaninchen-Komplement zu erklären, wird ein enhancing factor mit einer Spezifität gegen Neuraminidase behandelte antikörperbeladene Lymphocyten postuliert.     

The benzilic acid rearrangement of 3α,17β-Diacetoxy-11-hydroxy-12-oxo-5β-androst-9(11)-ene

Zusammenfassung Die Bildung von 11-Carboxy-3, 11, 17-trihydroxy-13-C-nor-5-androstan 11a,17-Lakton aus 3, 17-Diacetoxy-11-hydroxy-12-oxo-5-⁹(11)-androsten wird beschrieben. Der Mechanismus und die Stereochemie dieser Umwandlung (Retro-Aldolkondensation und Benzilsäureumlagerung) wird diskutiert.     

Ontogenic development and anatomical distribution of a supernumerary limb-inducing factor

. .

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This work was supported by a Rackham Grant from the University of Michigan.     

Ethanol influence on insulin secretion from isolated rat islets

Summary This study was done to delineate the role of - and -adrenergic receptors and cyclic AMP in the mechanism of ethanol effects on insulin release from isolated islets. Rats were given an -adrenergic blocker, phentolamine, or a -adrenergic blocker, propranolol. In addition, ethanol 1 g/kg was given intragastrically 1 h prior to sacrifice. Glucose mediated insulin release from isolated islets was enhanced by phentolamine and decreased by propranolol. Ethanol treatment inhibited glucose-induced insulin release from isolated islets of control rats as well as those given phentolamine and/or propranolol. Insulin release from isolated islets in response to dibutyryl-cyclic AMP was attenuated by ethanol. Theophylline enhanced glucose mediated insulin release from control islets but ethanol treatment produced a significant inhibition of insulin response. The data suggest that the site of action of the deleterious effects of ethanol on insulin release from isolated islets in rat does not involve adrenergic system and cyclic AMP.Supported by the U.S. Veterans Administration     

Starfish saponins VII. Structure of luzonicoside,a further steroidal cyclic glycoside from the pacific starfishEchinaster luzonicus

Summary On the basis of comparative chemical and spectral data, the structure of the major saponin, luzonicoside, from the starfishEchinaster luzonicus has been elucidated as2. This is a further example of a novel class of steroidal cyclic glycoside from starfish of the genusEchinaster. Its structure includes a ⁷, 3,6-dioxygenated-23-oxosteroidal moiety, already found in the saponins ofEchinaster sepositus, and a trisaccharide moiety, -D-galactopyranosyl-(12) -L-arabinopyranosyl-(12)--D-glucuronopyranosyl, bridging C-3 and C-6 of the steroid.This contribution is part of the Progetto Finalizzato Oceanografia e Fondi Marini del C.N.R., Roma.Acknowledgments. We wish to thank Mrs M. Pusset, Laboratoire des Plantes Médicinales du C.N.R.S., Nouméa, for the extraction of starfish and the divers of the Centre Q.R.S.T.O.M. de Nouméa for collection.     

Isoforms of baker's yeast transketolase

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Synthese von 5α- und 5β-Androstan-17β-ol-3-on-17-acetat aus Hyodesoxycholsäure

Summary 5- and 5-androstane-17-ol-3-one-17-acetate have been prepared from 5-androstane-6, 17-diol-3-one-17-acetate by a synthesis involving directedHuang-Minlon-reduction.Separation of 5-androstane-17-ol-3-one from its 5-isomer could readily be achieved by crystallisation of their 3-ethylenketals from acetone.     

Normalization by nucleotides of impairments in deamination of nitrogenous compounds in liver of tumor-bearing mice

-2 (3)--3- - .     

Cooperation between the two myosin heads interacting with actin in presence of ADP in myofibrils

Zusammenfassung Alkylierung von 2 Thiolgruppen pro Myosin mit NEM bei 0°C in Gegenwart einer Diophosphatkette inaktiviert die K-ATPase vollständig.In Myofibrillen werden diese Thiolgruppen durch Rigor-interaction beider Myosinköpfchen mit Actin vor Alkylierung geschützt. In Gegenwart von Mg-ADP tritt eine spezifische vom Rigor verschiedene interaction zwischen Myosin und Actin auf. Man muss annehemen, dass dabei nur 1 Myosinköpfchen ans Actin bindet und dass das andere Köpfchen ein ADP gebunden hat.     

Hydrolysis of amino acid β-naphthylamides by aminopeptidases in the parotid gland

Zusammenfassung Die Aktivität der Aminopeptidasen in Ohrspeicheldrüsen wurde gemessen. Glycyl-Prolin-naphthylamid, Alanin-naphthylamid, Leucin-naphthylamid, Methionin-naphthylamid, und Arginin-naphthylamid wurden von der Mikrosomenfraktion und der löslichen Fraktion schnell gespalten. Das Glycyl-Prolin-naphthylamid spaltende Enzym war in Ohrspeicheldrüsen in relativ grösserer Menge vorhanden. Die Aufspaltung von Glycyl-Prolin-naphthylamid in Glycyl-Prolin und-Naphthylamin wurde papierchromatographisch nachgewiesen.     

Interaction of polyene antibiotics and serum lipoproteins

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