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Chromatin assembly during S phase: contributions from histone deposition, DNA replication and the cell division cycle 总被引:7,自引:0,他引:7
During S phase of the eukaryotic cell division cycle, newly replicated DNA is rapidly assembled into chromatin. Newly synthesised
histones form complexes with chromatin assembly factors, mediating their deposition onto nascent DNA and their assembly into
nucleosomes. Chromatin assembly factor 1, CAF-1, is a specialised assembly factor that targets these histones to replicating
DNA by association with the replication fork associated protein, proliferating cell nuclear antigen, PCNA. Nucleosomes are
further organised into ordered arrays along the DNA by the activity of ATP-dependent chromatin assembly and spacing factors
such as ATP-utilising chromatin assembly and remodelling factor ACF. An additional level of controlling chromatin assembly
pathways has become apparent by the observation of functional requirements for cyclin-dependent protein kinases, casein kinase
II and protein phosphatases. In this review, we will discuss replication-associated histone deposition and nucleosome assembly
pathways, and we will focus in particular on how nucleosome assembly is linked to DNA replication and how it may be regulated
by the cell cycle control machinery. 相似文献
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El-Osta A 《Cellular and molecular life sciences : CMLS》2004,61(17):2135-2136
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DNA damage repair and transcription 总被引:2,自引:0,他引:2
Berardi P Russell M El-Osta A Riabowol K 《Cellular and molecular life sciences : CMLS》2004,61(17):2173-2180
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Regulation of transcription factor function by phosphorylation 总被引:1,自引:1,他引:0
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DNA mutations and aberrations are a problem for all forms of life. Eukaryotes specifically have developed ways of identifying and repairing various DNA mutations in a complex and refractory chromatin environment. The chromatin structure is much more than a packaging unit for DNA; it is dynamic. Cells utilize and manipulate chromatin for gene regulation, genome organization and maintenance of genome integrity. Once a DNA aberration has occurred, the various DNA repair machineries interact with chromatin proteins, such as the histone variant H2A.X, and chromatin remodeling machines of the SWI/SNF family to gain access and repair the lesion in a timely manner. Recent studies have thus begun to address the roles of chromatin proteins in DNA repair as well as to dissect the functions of DNA repair machinery in vitro on more physiological, nucleosomal templates. 相似文献
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Sry and Sox9: mammalian testis-determining genes 总被引:13,自引:0,他引:13
P. Koopman 《Cellular and molecular life sciences : CMLS》1999,55(6-7):839-856
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RNA-mediated gene silencing 总被引:21,自引:0,他引:21
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