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1.
Zusammenfassung Ein einfacher Weg zur selektiven Esterbildung mit der 5-Hydroxylgruppe von Thymidin wird beschrieben. Beispiele: Thymidin-5-phosphat, Thymidin-5-sulfat und Thymidin-5-trichloracetat. 相似文献
2.
P. Divakaran B. M. Rigor R. C. Wiggins 《Cellular and molecular life sciences : CMLS》1980,36(6):655-656
Summary Adults rats were exposed to 0.5, 1.0 and 1.5% halothane, delivered in air, for 1 h. Whole brain 3,5-cyclic adenosine monophosphate (cAMP) of halothane-exposed rats showed only a slight increase relative to control values. 3,5-Cyclic guanosine monophosphate (cGMP) was increased significantly in halothane-exposed rats, and the response was directly related to the halothane concentrations. Adenosine triphosphate (ATP) and phosphocreatine (PC) remained unchanged relative to control values. Correspondence of these values to apparent discrepancies in the literature is discussed.Acknowledgments. This research was supported by Public Health Service Grant NS-14355. 相似文献
3.
Summary The axial (ax.) and equatorial (eq.) diastereomeric forms of phosphate triesters resulting from reactions of N-ethyl, N-nitrosourea with 3 cyclic mononucleotides were analyzed by column liquid chromatography (CLC). Evidence is presented that the 2OH group of 3, 5cAMP essentially contributes to the stereoselective eq. alkyl substitution, most probably by hydrogen bonding catalysis. The neighboring group direction of ethylation gives substantial support to non-random DNA alkylations by NEU.We acknowledge the helpful cooperation of Dr Fritz Eckstein, M.P.I. for Exp. Medicine, Göttingen, who determined the31P-N.M.R. spectra of the diastereomeric forms of the neutral ethylester of 3, 5 cAMP. This work has been supported by a personal grant to one of us (Sta 131/6 PAN) from the Deutsche Forschungsgemeinschaft. Reprint requests to K.-W. Stahl. 相似文献
4.
J. Křivánek 《Cellular and molecular life sciences : CMLS》1980,36(10):1185-1186
Summary The effect of potassium ions on the formation of adenosine 3,5-monophosphate (cAMP) in the rat cerebral cortex in vivo was studied under conditions where development of spreading depression had been blocked by pretreatment of the cerebral cortex by topically applied magnesium ions. A linear relationship between potassium concentrations applied to the cortical surface and levels of cAMP has been found. Moreover, potentiation of the K+-effect by magnesium ions has been observed. 相似文献
5.
Hotspots of homologous recombination 总被引:9,自引:0,他引:9
G. R. Smith 《Cellular and molecular life sciences : CMLS》1994,50(3):234-241
Homologous recombination occurs at higher than average frequency at and near hotspots. Hotspots are special nucleotide sequences recognized by proteins that promote, directly or indirectly, a rate limiting step of recombination. This review focuses on two well-studied examples, the Chi sites of the bacteriumEscherichia coli and the M26 site of the fission yeastSchizosaccharomyces pombe. Chi, 5 G-C-T-G-G-T-G-G 3, is recognized by the RecBCD enzyme, which nicks the DNA near Chi and produces a 3-ended single-stranded DNA tail; this tail is a potent substrate for homologous pairing by RecA and single-stranded DNA binding proteins. M26, 5 A-T-G-A-C-G-T 3, is recognized by a heterodimeric protein and stimulates, by an as-yet-unknown mechanism, meiotic recombination at and near theade6 gene. Additional hotspots in bacteria, fungi, and mammals enhance recombination directly or indirectly via a variety of mechanisms. Although hotspots are widespread among organisms, the biological role of their localized enhancement of recombination remains a matter of speculation. 相似文献
6.
2O, 6N-butyryl, 3', 5'-cyclic monophosphate (dibu cAMP) when added to fetal rat heart cells in culture inhibits myocyte contraction. This inhibition is 100, 84 and 51% complete when the dibu cAMP concentration used is 2, 0.2 and 0.02 mM, respectively. The potency of dibu cAMP derivatives in myocyte contraction inhibition follows the order, dibu cAMP greater than 6N-bu cAMP greater than 2O-bu cAMP = AMP greater than butyrate. The inhibition caused by the first three chemicals is greater than 70%. 相似文献
7.
P. C. Srivastava K. L. Nagpal M. M. Dhar 《Cellular and molecular life sciences : CMLS》1969,25(4):356-357
Zusammenfassung Uridylyl-(3–5)-adenosin und Uridylyl-(3-5)-ionosin wurden durch Umsetzung eines passenden 5-chloro-5-deoxy-2, 3-O-isopropylidene-Nukleosids mit Uridin-3-phosphat synthetisiert. 相似文献
8.
Zusammenfassung Die Synthese von 7-Hydroxy-5,6-dimethoxybenzofurano[3,2:3,4]coumarin aus 7,2-Dihydroxy-oder 7-Benzyloxy-2-hydroxy-4,5-dimethoxyisoflavon wird beschrieben. 相似文献
9.
Zusammenfassung Die Injektion von N6-2-O-Dibutyryl-adenosin-3 5-monophosphat in den lateralen Hirnventrikel von Kaninchen führt zu einer langanhaltenden Fieberreaktion, was vermuten lässt, dass zyklisches Adenosin-35-monophosphat als weiterer Mediator in der Genese des Fiebers fungiert. 相似文献
10.
H. R. Gutmann 《Cellular and molecular life sciences : CMLS》1964,20(3):128-129
Zusammenfassung Im Gegensatz zu neueren Befunden von anderen Autoren finden wir, dass die Oxydation von 2-Fluorenamin oder 4-Aminodiphenyl mit Peressigsäure keine Nitrosoderivate bildet, sondern die Azoverbindungen 2,2-Azoxybisfluoren und 4,4-Azobisdiphenyl.p-Nitroanilin wird zu einem Gemisch oxydiert, aus dem manp, p-Dinitroazoxybenzol undp, p-Dinitroazobenzol durch Chromatographie an Kieselgel isolieren kann.
Supported by a grant (C-2571) from the National Cancer Institute, U.S. Public Health Service. 相似文献
Supported by a grant (C-2571) from the National Cancer Institute, U.S. Public Health Service. 相似文献
11.
J. Pórszász Katalin Gibiszer-Pórszász S. Földeák B. Matkovics 《Cellular and molecular life sciences : CMLS》1965,21(2):93-94
Zusammenfassung Ein neues Diindolyl-methan-derivat, das N, N-di(piperidino-methyl)-3, 3-diindolyl-methan, wurde synthetisiert; es verursacht im Tierversuch schon in Dosen von 3–5 mg/kg einen langanhaltenden zentralen Depressoreffekt. 相似文献
12.
A2 adenosine receptors were characterized in human glomerular mesangial cells using [3H] 5-N-ethylcarboxamidoadenosine (NECA) as a tracer. There was a single group of receptor sites with a KD of 184 nM, and a number of sites of 317 fmol/mg of cell protein. Adenosine agonists increased 5-nucleotidase activity via A2 receptor stimulation. The specific A2 agonist-NECA, at 0.1 and 1 m, was a potent inhibitor of DNA synthesis. 相似文献
13.
Summary In vitamin K deficient chicken the serum complement (C) level is significantly decreased, as compared with normal animals, due to a lower level of its component C1. Administration of vitamin K1 for three days did not restore its titer although the prolonged blood clotting time became normal. The results thus indicate a considerably slower resynthesis of the complement factor C1 than of prothrombin. 相似文献
14.
Th. M. Konijn 《Cellular and molecular life sciences : CMLS》1970,26(4):367-369
Zusammenfassung Es wird ein mikrobiologisches Testverfahren beschrieben, mit dem sehr geringe Mengen von zyklischem Adenosin 3, 5-monophosphat quantitativ nachgewiesen werden können. 相似文献
15.
Y. Kaneko Y. Imai F. Matsuzaki Y. Endo T. Oda 《Cellular and molecular life sciences : CMLS》1979,35(12):1660-1661
Summary Epidermal growth factor stimulated both [3H]thymidine uptake and proliferation of rat AH66 hepatoma cells. However, the increase in cell number was not accompanied by a proportional increase in the levels of -fetoprotein of the culture media. The effects of EGF on the cell proliferation were antagonized by N6, O2-dibutyryl cAMP. 相似文献
16.
R. R. Scheline 《Cellular and molecular life sciences : CMLS》1974,30(8):880-881
Zusammenfassung Nach Eingabe vontrans-Stilben bei Ratten wurden die grössten Mengen im Harn als 3,4,4-Trihydroxystilben, 3,4,4-Trihydroxybibenzyl und 3,3, 4,4-Tetrahydroxybibenzyl nachgewiesen. Die Bibenzylderivate werden nachscheinlich nach Ausscheidung in der Galle von Darmbakterien metabolisiert. 相似文献
17.
W. E. G. Müller 《Cellular and molecular life sciences : CMLS》1976,32(12):1572-1573
Summary 1--d-arabinofuranosylcytosine-5-triphosphate and 9--d-arabinofuranosyladenosine-5-triphosphate were found to have no inhibitory potency for both mammalian DNA-dependent RNA polymerase II andE. coli DNA-dependent RNA polymerase. 相似文献
18.
Zusammenfassung Mit Meerschweinchen-Komplement sensibilisierte Schaferythrocyten (EAC1,4,2) wurden einerseits mit Meerschweinchen-, andererseits mit menschlichem C3 in Intermediärform (E*) gebracht. Sie wurden im ersten Fall rascher lysiert, als im zweiten Fall. Es wird vermutet, dass hauptsächlich die EAC1,4,2 + C3-Reaktion für die unterschiedliche Wirkung von Meerschweinchen- und menschlichem Komplement in der Terminalphase der Hämolyse verantwortlich ist. 相似文献
19.
Zusammenfassung Eine einfache Synthese von Dehydromunduseron aus 7,2,4,5-Tetramethoxy-isoflavon wird beschrieben. 相似文献
20.
V. M. Varagić Milena Žugić B. B. Mršulja 《Cellular and molecular life sciences : CMLS》1972,28(3):305-306
Résumé Le dérivé dibutyrique du 3, 5-AMP cyclique potentialise les contractions du diaphragme provoquées par stimulation électrique indirecte, alors que l'application du 3,5-AMP cyclique n'a pas un tel effet. D'autre part, ce dérivé diminue le taux de glycogène du diaphragme, ce qui n'est pas le cas pour le 3,5-AMP cyclique. 相似文献