| 猪皮胶原肽-锌螯合物的制备工艺研究 |
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| 引用本文： | 猪皮胶原肽-锌螯合物的制备工艺研究.猪皮胶原肽-锌螯合物的制备工艺研究[J].山东科学,2010,33(3):53-61. |
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| 作者姓名： | 猪皮胶原肽-锌螯合物的制备工艺研究 |
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| 作者单位： | 山东中医药大学 药学院，山东 济南 250355 |
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| 基金项目： | 国家级大学生创新训练计划（201910441013） |
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| 摘 要： | 研究猪皮胶原肽-锌螯合物的制备工艺。以猪皮为原料，制备猪皮胶原肽-锌螯合物；以螯合率为指标，研究了猪皮胶原肽与锌质量比、pH、温度、时间对螯合率的影响；通过单因素试验、响应面法试验考察优化猪皮胶原肽的富锌工艺。结果显示，猪皮肽-锌螯合的最佳工艺为猪皮肽与锌质量比2:1，螯合pH 7.0，螯合温度50 ℃，螯合时间50 min，在此条件下，试验螯合率最佳，为69.27%，与模型预测值69.92%相近。该研究为新型生物肽 锌螯合物的研制、猪皮的高值化利用提供了依据。
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| 关 键 词： | 猪皮胶原肽 酶解 锌元素 螯合工艺 响应面法 |
Investigation on preparation process of pigskin collagen peptide-zinc chelate |
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| WU Jia-jin,BIAN Zhi-jie,ZHU Yue,ZHANG Xue-tao,PANG Li-dan,GAO Peng.Investigation on preparation process of pigskin collagen peptide-zinc chelate[J].Shandong Science,2010,33(3):53-61. |
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| Authors: | WU Jia-jin BIAN Zhi-jie ZHU Yue ZHANG Xue-tao PANG Li-dan GAO Peng |
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| Affiliation: | School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China |
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| Abstract: | This paper studies the preparation process of pigskin collagen peptide-zinc chelate. Pigskin was used as a raw material to prepare the pigskin collagen peptide-zinc chelate, and the effect of mass ratio of pigskin collagen peptide and zinc, pH, temperature, and time on the chelating rate, which was used as the index, was studied. We used a single-factor method and the response surface method to investigate zinc-rich technology of pigskin peptide. The results showed that the best technology for pigskin peptide-zinc chelation involved pigskin peptide-zinc mass ratio of 2:1 and a process with pH 7.0, 50 ℃, and 50 min for the chelation, resulting in the highest chelating rate of 69.27%, which was close to the predicted 69.92%. This study provides a basis for the development of new biological peptide-zinc chelation and the maximum utilization of pigskin. |
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| Keywords: | pigskin collagen peptide enzymatic hydrolysis zinc chelation process response surface methodology |
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