首页 | 官方网站   微博 | 高级检索  
     

模拟失重效应下龙血素B在大鼠体内的药物动力学及排泄
引用本文:陈博,张宇实,苏靖,王睿,邓玉林,李玉娟.模拟失重效应下龙血素B在大鼠体内的药物动力学及排泄[J].北京理工大学学报,2017,37(8):875-880.
作者姓名:陈博  张宇实  苏靖  王睿  邓玉林  李玉娟
作者单位:北京理工大学生命学院,北京,100081;中国中医科学院中药研究所,北京,100029;河北省邢台市第三医院,河北,邢台 054000
基金项目:国家自然科学基金资助项目(81573693);国家重大仪器专项基金资助项目(2012YQ040140);1226重大基金资助项目(AWS16J018)
摘    要:比较正常重力与模拟失重效应下大鼠口服龙血素B的血浆药物动力学及排泄差异.大鼠吊尾21 d模拟失重效应,单次灌胃给予25 mg/kg龙血素B.于系列时间点收集静脉血,并分时间段收集尿液、粪便和胆汁,采用HPLC-MS方法测定各样本中龙血素B含量,并求算药物动力学参数和排泄量.模拟失重效应下龙血素B的血药浓度-时间曲线下面积(AUC0-t)、血药峰浓度(Cmax)、达峰时间(tmax)、表观分布容积(Vd)、消除速率常数(Ke)以及生物半衰期(T1/2)与正常重力组相比均出现显著变化,说明模拟失重效应明显改变龙血素B在大鼠体内的药物动力学过程.尿液、粪便和胆汁中龙血素B的排泄量也在增加,但与正常重力相比不明显. 

关 键 词:模拟失重  龙血素B  药物动力学  药物排泄
收稿时间:2016/3/3 0:00:00

Study on Pharmacokinetics and Excretion of Loureirin B in Rats Under Simulated Weightlessness Condition
CHEN Bo,ZHANG Yu-shi,SU Jing,WANG Rui,DENG Yu-lin and LI Yu-juan.Study on Pharmacokinetics and Excretion of Loureirin B in Rats Under Simulated Weightlessness Condition[J].Journal of Beijing Institute of Technology(Natural Science Edition),2017,37(8):875-880.
Authors:CHEN Bo  ZHANG Yu-shi  SU Jing  WANG Rui  DENG Yu-lin and LI Yu-juan
Affiliation:1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China;2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100029, China;3. Xingtai Third Hospital, Xingtai, Hebei 054000, China
Abstract:To study pharmacokinetics and excretion difference of loureirin B (LB) in rats after single oral administration between simulated weightlessness and gravitation condition, a series of test was executed. Rats were tail-suspended for 21 days to simulate weightlessness effect. After a single oral administration of 25 mg/kg LB, venous blood and excretion samples were collected at different time points. Concentration of LB in samples was determined by HPLC-MS method. Pharmacokinetic parameters and excretion amount were calculated. Results show that, compared with normal gravity rats, the area under cuve (AUC0-t), maximum concentration (Cmax), time to peak concentration (tmax), volume of distribution (Vd), elimination rate constant (Ke), and biological half-life (T1/2) of simulated weightless rats ware significantly changed. Meanwhile, the excretion of LB in urine, feces, and bile are also up-regulated in simulated weightlessness group, while no obvious differences are observed.
Keywords:simulated weightlessness  loureirin B  pharmacokinetics  excretion
本文献已被 CNKI 万方数据 等数据库收录!
点击此处可从《北京理工大学学报》浏览原始摘要信息
点击此处可从《北京理工大学学报》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司    京ICP备09084417号-23

京公网安备 11010802026262号