| 智能海藻酸钙/PNIPAAm互穿网络水凝胶微囊制备研究 |
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| 引用本文： | 许立新,王秀芬,甘霓,张立群.智能海藻酸钙/PNIPAAm互穿网络水凝胶微囊制备研究[J].北京化工大学学报(自然科学版),2005,32(1):55-58. |
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| 作者姓名： | 许立新 王秀芬 甘霓 张立群 |
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| 作者单位： | 北京化工大学1可控化学反应科学与技术基础教育部重点实验室; 2 纳米材料先进制备技术与应用科学教育部重点实验室，北京 100029 |
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| 摘 要： | 以海藻酸钙凝胶为聚合模板，过硫酸铵/偏重亚硫酸钠氧化还原引发剂体系、自由基水溶液法聚合制备了温度敏感和pH敏感的海藻酸钙/聚N异丙基丙烯酰胺（CA/PNIPAAm）互穿网络水凝胶微囊。并研究了引发剂用量、单体量、单体/海藻酸钠配比、缓冲液pH值等因素对该互穿智能水凝胶温度敏感和pH敏感性的影响。结果表明：该互穿凝胶微囊对pH/温度具有敏感溶胀性，可望作为口服药物缓释制剂的载体。
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| 关 键 词： | 海藻酸钙 PNIPAAm 互穿网络水凝胶微囊 温度敏感 pH敏感性 海藻酸钙 PNIPAAm 互穿网络水凝胶微囊 温度敏感 pH敏感性 |
| 收稿时间： | 2004-07-09 |
| 修稿时间： | 2004年7月9日 |
Preparation of intelligent calcium alginate/PNIPAAm interpenetrating network hydrogel beads |
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| XU Li xin,WANG Xiu fen,GAN Ni,ZHANG Li qun.Preparation of intelligent calcium alginate/PNIPAAm interpenetrating network hydrogel beads[J].Journal of Beijing University of Chemical Technology,2005,32(1):55-58. |
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| Authors: | XU Li xin WANG Xiu fen GAN Ni ZHANG Li qun |
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| Affiliation: | 1.The Key Laboratory of Science and Technology of Controllable Chemical Reactions, Ministry of Education; 2.Key Laboratory for Nanomaterials,Minstry of Education, Beijing University of Chemical Technology, Beijing 100029,China |
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| Abstract: | A thermo and pH sensitive interpenetrating network hydrogels beads were prepared with both calcium alginate and PNIPAAm hydrogels which were synthesized by free radical aqueous solution polymerization using APS(ammonium persulphate)/Na 2S 2O 5(Sodium pyrosulfite) as redox initiators in a simultaneous interpenetrating network process. The effects of the initiator concentration,monomer concentration, NIPAAm/alginate ratio, the solution pH values on the gel swelling performance in different temperatures and pH solutions were discussed. Results show that the IPN hydrogel beads exhibit thermo and pH sensitive swelling ratio characteristics. Therefore, the IPN hydrogels may be useful in the field of controlled drug delivery. |
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| Keywords: | calcium alginate PNIPAAm interpenetrating network hydrogels beads thermosensitive pH sensitive |
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