| HPLC法测定阿司匹林经皮给药贴剂中阿司匹林的含量 |
| |
| 引用本文： | 杜洪光,侯志芬,柯光明,张爽,王树明.HPLC法测定阿司匹林经皮给药贴剂中阿司匹林的含量[J].北京化工大学学报(自然科学版),2005,32(3):110-112. |
| |
| 作者姓名： | 杜洪光 侯志芬 柯光明 张爽 王树明 |
| |
| 作者单位： | 1. 北京化工大学理学院， 北京 100029；2. 北京康倍得医药技术开发有限公司， 北京 100089 |
| |
| 摘 要： | 建立阿司匹林贴剂含量的测定方法。乙腈为阿司匹林贴剂的萃取溶剂，用Waters公司Symmetry ShieldTM RP18柱(3.9mm×150mm, 5μm)，流动相：乙腈-0.01mol·L-1的磷酸氢二钠（磷酸调pH值至2.50）；体积比为25∶75；检测波长234nm；流速10mL·min-1。阿司匹林在3～96μg·mL-1范围内呈现良好的线性关系，r=0.9993。阿司匹林回收率为100.3%，RSD为0.42%。本方法简单、灵敏、准确，可作为该制剂内在质量的控制方法。
|
| 关 键 词： | 阿司匹林 高效液相色谱法（HPLC) 经皮给药贴剂 阿司匹林 高效液相色谱法（HPLC) 经皮给药贴剂 |
| 收稿时间： | 2004-07-02 |
| 修稿时间： | 2004年7月2日 |
Determination of Aspirin in transdermal delivery patch by HPLC |
| |
| DU Hong-guang,HOU Zhi-fen,KE Guang-ming,ZHANG Shuang,WANG Shu-ming.Determination of Aspirin in transdermal delivery patch by HPLC[J].Journal of Beijing University of Chemical Technology,2005,32(3):110-112. |
| |
| Authors: | DU Hong-guang HOU Zhi-fen KE Guang-ming ZHANG Shuang WANG Shu-ming |
| |
| Affiliation: | 1. College of Science, Beijing University of Chemical Technology, Beijing 100029；2. Beijing KBD Pharmaceutical Technology Development Co.Ltd., Beijing 100089,China |
| |
| Abstract: | A method for measurement of aspirin in the patch was developed with the high performance liquid chromatography (HPLC). Acetonitrile was used as extracted solution. Symmetry ShieldTM RP18 column was adopted and the mobile phase was composed of acetonitrile-0.01mol·L-1 di-sodium hydrogen phosphate (adjusting pH to 2.50 with phosphoric acid). A linearity with a good correlation coefficient was yielded from 3 to 96μg·mL-1 for aspirin (r=0.9993). The average recovery was 100.3% and RSD was 0.42%. This method is simple, sensitive and accurate, and can be used for the quality control of the patch. |
| |
| Keywords: | aspirin high performance liquid chromatography (HPLC) trandermal drug delivery patch |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《北京化工大学学报(自然科学版)》浏览原始摘要信息 |
|
点击此处可从《北京化工大学学报(自然科学版)》下载全文 |
