| G蛋白偶联受体:七次跨膜结构的超级分子——2012年诺贝尔化学奖简介 |
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| 引用本文： | 路伟振,吴蓓丽,赵强.G蛋白偶联受体:七次跨膜结构的超级分子——2012年诺贝尔化学奖简介[J].自然杂志,2012,34(6):337-343. |
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| 作者姓名： | 路伟振 吴蓓丽 赵强 |
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| 作者单位： | 1.硕士，23研究员，中国科学院上海药物研究所，中国科学院受体结构与功能重点实验室，上海201203 |
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| 摘 要： | G蛋白偶联受体是人类基因组中最大也是最重要的一类蛋白质，它们几乎参与了生物体中所有的生命活动。这一类受体的发现、功能研究以及结构解析为我们了解生理调控以及疾病的发生与治疗等带来新的曙光。在此之前，G蛋白偶联受体的相关研究已经被九次授予诺贝尔奖，而2012年，诺贝尔化学奖再次授予Robert J. Lefkowitz和Brian K. Kobilka，以表彰他们在此领域，尤其是肾上腺素受体上的相关研究。文中简介了G蛋白偶联受体的研究历程，其独特的七次跨膜结构与激活机制，并对此领域的未来发展做了展望。
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| 关 键 词： | G蛋白偶联受体 肾上腺素受体 七次跨膜结构 |
| 收稿时间： | 2012-11-20 |
G Protein Coupled Receptors,the Magic Molecules with Seven Transmembrane Helices: A Brief Introduction to the Nobel Prize in Chemistry 2012 |
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| LU Wei-zhen
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WU Bei-li
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ZHAO Qiang.G Protein Coupled Receptors,the Magic Molecules with Seven Transmembrane Helices: A Brief Introduction to the Nobel Prize in Chemistry 2012[J].Chinese Journal of Nature,2012,34(6):337-343. |
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| Authors: | LU Wei-zhen WU Bei-li ZHAO Qiang |
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| Affiliation: | 123.Professor, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | G protein coupled receptors are the largest and the most important protein family in human genome, which involved in almost all of the living activities. The gene cloning, functional studies and structural determination of these receptors shed a new light on understanding the physiological regulation and the pathogenicity and treatment of almost all the human diseases. The Nobel Prize had issued to related research for 9 times, and in 2012, the Nobel Prize in Chemistry was issued to two American scientists, Robert J. Lefkowitz and Brian K. Kobilka, for their extraordinary work on this area, especially on β2 adrenergic receptors. In this paper, we briefly reviewed the research progresses of G protein coupled receptors in the past, their unique 7 transmembrane architecture, activation mechanism and their future trends. |
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| Keywords: | G protein coupled receptor adrenergic receptor 7 transmembrane architectur |
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