| 中性粒细胞胞外诱捕网在痛风性关节炎中的作用：一枚硬币的两面 |
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| 引用本文： | 王雪霖,曹秀梅,闫建设.中性粒细胞胞外诱捕网在痛风性关节炎中的作用：一枚硬币的两面[J].自然杂志,2021,43(2):135-140. |
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| 作者姓名： | 王雪霖 曹秀梅 闫建设 |
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| 作者单位： | 1.上海大学 生命科学学院，上海 200444；2上海交通大学 医学院，上海市免疫学研究所，上海 200025 |
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| 基金项目： | 国家自然科学基金项目(31972901、31671234、31571430) |
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| 摘 要： | 痛风性关节炎(gouty arthritis, GA)是一种由大量单钠尿酸盐(monosodium urate, MSU)沉积所导致的急性炎症。MSU晶体引发中性粒细胞胞外诱捕网(neutrophil extracellular traps, NETs)的产生，后者诱发粒细胞和单核细胞释放
促炎细胞因子和趋化因子，使炎症反应进一步加剧。NETs的大量形成会对晶体进行包埋降解，抑制炎症扩散。文章概述了GA的发生、发展及自我缓解过程中中性粒细胞在其中所起到的双重作用，以及参与中性粒细胞NETs形成的相关信号通路。
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| 关 键 词： | 痛风性关节炎 中性粒细胞胞外诱捕网 单钠尿酸盐 |
| 收稿时间： | 2020-11-05 |
The role of neutrophil extracellular traps in gouty arthritis: two sides of the same
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| WANG Xuelin,CAO Xiumei,YAN Jianshe.The role of neutrophil extracellular traps in gouty arthritis: two sides of the same
coin[J].Chinese Journal of Nature,2021,43(2):135-140. |
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| Authors: | WANG Xuelin CAO Xiumei YAN Jianshe |
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| Affiliation: | 1.School of Life Sciences, Shanghai University, Shanghai 200444, China;2.Shanghai Institute of Immunology, School of Medicine,
Shanghai Jiao Tong University, Shanghai 200025, China |
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| Abstract: | Gouty arthritis (GA) is an acute inflammatory that is initiated by the precipitation of oversaturated solutions of uric acid as
monosodium urate (MSU) crystals, which activates neutrophils to release neutrophil extracellular traps (NETs). NETs further enhance
the inflammatory response by inducing neutrophils and monocytes to release pro-inflammatory cytokines and chemokines. However,
the increasing number of neutrophils recruited to the sites of MSU deposits allows the formation of aggregated NETs that densely
packs MSU crystals and degrades the proinflammatory cytokines, thereby allowing turning down the inflammatory. Here we briefly
summarize the dual role of neutrophils during the initiation, development and the resolution of GA, and the signal pathways involved
in the regulation of NETs formation. |
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