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Immunogenicity of formaldehyde and binary ethylenimine inactivated infectious bursal disease virus in broiler chicks
Authors:Mudasser Habib  Iftikhar Hussain  Hamid Irshad  Zong-zhao Yang  Jiang-bing Shuai  and Ning Chen
Abstract:Infectious bursal disease virus (IBDV) was inactivated by two different chemicals—formaldehyde and binary ethylenimine (BEI). Formaldehyde was used at 0.1% and 0.2%, while BEI was used at concentrations of 0.001 and 0.002 mol/L. These four vaccines were tested for their efficiency in generating humoral immune response in different groups of broiler chicks. Both BEI-inactivated vaccines gave relatively higher antibody titers and were almost twice as efficient as formaldehyde-inactivated ones.
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