To explore the potential protective effect of cyaniding-3-glucoside on lead-induced liver and kidneys damage in rats, 20 males SD rats were choosen and then randomly divided into four group. Different dose of anthocyanins are intragastric administration, lead solution are intraperitoneal injection at the same time, for 5 days successively treatment. After the last treatment 12h,weighing the bodyweight of rats and collect the serum, liver and kidnys sample to detect. ALT、AST of liver damage index and urea、creatinine of kidneys damage index are measured. Part of liver and kidney are used to paraffin embedding, sectioning for pathology examination. The results show obviously organ coefficentchanges(P<0.05)and significantly liver and kidneys damage of lead exposed group. Sreum ALT, AST, Urea and creatinine show a downward trend in these protection groups. Also, the water and fatty denaturetion of liver and the vacuoles of cell and the narrow change, tube type of protein of renal tubular etc pathological changes showd different degrees of improvement. All the find of the study have shown that cy-3-glu have the clearly protection on lead induced liver and kidneys damage, the mechanism of this need further research.