The relative positions of centroid, bending center and pressure center of aerofoil have an important influence on the flight performance, safety and ride quality of an aircraft. In this paper, the centroid and bending center of large aspect ratio aerofoil are changed by adjusting the weight of the structure and the position of the main beam along the chord direction. The influence of the relative positions of the centroid, bending center and the pressure center on the aerodynamic response of the aerofoil are analyzed by CFD/CSD. The results show that the centroid has a great influence on the dynamic response of the aerofoil. The response of the tip-wing displacement will be the intensest if the centroid is in front position. But when the centroid is relatively backward, the first-order aerofoil torsion response will be intensest. When the bending center moves backwards, the maximum amplitude of the tip-wing displacement gradually increases, but the tip-wing torsional angle simultaneously decreases. Bending centers should be set after the pressure center. When the bending is placed before the pressure center, and the centroid is placed behind the bending center, the aerofoil will twist and then diverge.