Abstract: In accordance with the characteristic of starting pressure gradient and stress sensitivity existed in low permeability reservoirs, and considering the variety of oil relative permeability, oil viscosity and volume coefficient of oil in different pressure, the inflow performance equation of the oil, gas and water simultaneous seepage flow in low permeable reservoirs has been established considering the starting pressure gradient and stress sensitivity. The factors of effect on the shape of inflow performance curve has been analyzed. It is significant for the prediction of inflow performance of oil well in low permeability reservoirs developed.