The disturbance of stratum deformation caused by pipe jacking construction has become one of the important factors affecting the safety of municipal engineering and the surrounding environment. We take the construction of the sewage pipe network under the Harmony Avenue in the gravel stratum of the Cixian section of the Middle Route Project of South-to-North Water Diversion as an example. Theoretic prediction and field test research on ground settlement deformation under pipe jacking construction disturbance were carried out. The theoretical prediction model parameters are optimized and revised, which is based on the actual measurement results on site. The results show that: when the formation volume loss rate is controlled within 6.9%, the surface subsidence near Harmony Avenue in Ci County meets the safety requirements of the relevant specifications; the maximum surface subsidence within the construction scope of the sewage pipe network of the Ci County section of the Middle Route Project of South-to-North Water Diversion is between 2.5 and 4 mm, which does not exceed the safety threshold; for similar conditions, the recommended values of ground loss ratio and settlement tank width index are 3.31% and 0.525, respectively. The related research results provide reference for the study of ground deformation prediction under similar conditions.