In order to study the source of sediments from the Ganjiang River and the crustal growth history of source region, In this paper, representative 80 zircons was measured for Hf isotopic composition of 123 the Ganjiang River’s detrital zircon which has been reported. The detrital zircon U-Pb age distribution of sediments from the Ganjiang River is consistent with those of the Cathaysia Block, which indicates dominant contribution of material from the Cathaysia Block to the Ganjiang River. The detrital zircon U-Pb ages and Hf isotopic composition of the Ganjiang River’s sediments can reflect the formation and evolution history of the Cathaysia Block. The εHf(t) values of the Neoarchean detrital zircons approximately 0, it shows that the strong crust mantle mixing occurred in this period; εHf(t) values of the Mesoproterozoic and Neoproterozoic detrital zircons have both positive and negative values, indicated that the material of the source region is not only the recycling of ancient crustal materials, but also the addition of new crustal material; most of the εHf(t) is negative since Phanerozoic and the age of two stage mode corresponding to the Paleoproterozoic to Mesoproterozoic, indicated that the magmations after phanerozoic eon are most derived from the juvenile crust formed in paleoproterozoic- Mesoproterozoic, and little of them derived from depleted mantle. Meanwhile 2.1Ga-1.1Ga is the main stage that Cathaysia Block continental growth evolved from depleted mantle to the crust, and material that formed in this stage constitute 80% of the Cathaysia Block crust material.