Abstract: The related problems of surrounding rock plastic zone in non-isobaric circular roadway are important factors affecting the surrounding rock failure and instability. Firstly, based on Mohr-Coulomb failure criterion, the boundary conditions of plastic zone in non-isobaric circular roadway were analyzed, and the influence mechanism of lateral pressure coefficient on the formation of plastic zone was investigated. In addition, ANSYS/LS-DYNA simulation platform was used to simulate the static and dynamic load coupling mechanical response behaviour of the roadway surrounding rock under different lateral pressure coefficients. The results show that the increase of lateral pressure coefficient significantly changes the distribution characteristics of the effective stress in the surrounding rock. The distribution characteristics of the effective stress field are consistent with the theoretical solution of the plastic zone boundary. There is a significant difference in the deformation of roadway surrounding rock under the action of the stress field with different lateral pressure coefficient. As the lateral pressure coefficient increases, a large non-uniform deformation occurs in surrounding rock. The surrounding rock failure area of the roof and floor increases significantly under static and dynamic coupling, but the surrounding rock failure area of the two sides tends to decrease.