In order to determine the rolling process for improving the quality of the center of the heavy gauge plate, the traditional and new rolling process rolling pass schedule for producing 100 mm thick plate are formulated. By analyzing the macrostructure, microstructure and inclusion composition, the effects of roughing rolling, finishing rolling and speed on the center segregation and center porosity are studied. The results show that the segregation of P and S exists in the center of the heavy gauge steel plate, and there are inclusions of alumina, silicate and MnS. In the roughing rolling stage, the new rolling pass schedule has a superposition effect on the variable accumulated austenite, which is more advantageous to eliminate the central segregation and the central porosity. In finishing rolling stage, multi pass and longtime rolling are beneficial to the elimination of central segregation and central porosity. When the shape ratio is 0.5 ~ 1.0, low-speed rolling is beneficial to the elimination of central segregation and central porosity. The critical condition for the elimination of center segregation and center porosity is that the shape ratio is greater than 0.518, and it is more effective to use the shape ratio to formulate the rolling pass schedule than the pass reduction rate to eliminate center segregation and center porosity.