Since barium sulfate compact structure and generally insoluble in acid,for such duty the most effective solution is to inject water by adding chemical inhibitors. The performance of five scale inhibitions DETPMP、EDTMPS、GY-405、HX-1、AMPS and their combination was investigated by Barium ion complexometric titration method. Choose the better complex-type inhibitors, reuse orthogonal test scale inhibitor formulation. When two kinds of scale inhibitor cooperated, the effect of scale inhibitor GY-405 with DETPMP was best, and when GY-405:DETPMP was 2:1, the scale inhibition rate reached to 62.36%. The synergistic effect of the ternary system was even better, system GY-405, DETPMP, AMPS concentrations were 25mg/L, 25mg/L, 15mg/L showed the best anti-scaling performance. The effect of temperature, Ba2+ concentration, pH，and salinity on the scale inhibiting performance of ternary system was studied by the orthogonal experiment too. The orthogonal experiment results showed that under the conditions of Ba2+ concentration at 800 mg/L, the pH at 7, the temperature at 75℃ and the salinity at 42g/L, the scale inhibition rate was the maximum. The sequenceof the influence on the barium sulfate scale inhibition effect among the four factors was as follows, Ba2+concentration> pH> salinity> temperature.