Aiming at the problems of complex operation and fixed beam direction in array optimization under multiple constraints, this paper proposes a synthesis method based on mixed integer directed differential evolution (MIDDE) algorithm. First, the number of optimization targets is reduced, the optimization space is reduced, and the com-putational complexity is reduced through geometric transformation; Secondly, random selection and sorting strategy are introduced into the mutation process of differential evolution (DE) algorithm to improve the search speed and accuracy, and the boundary constraint processing method is improved to improve the boundary search ability. Finally, MIDDE algorithm is used to optimize the objective function of the regularized robust super directed beamformer. The simulation results show that under the constraint of white noise gain (WNG), the optimized array can obtain a higher directivity factor (DF) in a wide beam pointing angle range, which is significantly higher than the regular array with the same number of elements. This method can effectively improve the array performance.