Abstract: To study the damage effect of simultaneous explosion of two charges in different cabin structure, some explosion tests were carried out for the condition, TNT charges with the same mass, explosion in single and four cabins with simulated cabin structure. The tests were arranged to analyze the matching relationship between charge mass and cabin volume, and the influence of charges location on the damage effect of four layer cabins. The results show that group charge detonation in single layer cabin can result in the serious tearing and throwing, but the damage effect of the whole structure is not remarkable. According to the damage quantity of cabin, the damage effect of two charges (the mass of each charge equals 1/2 mass of group charge) in two different cabins is better than that of group charge with the same mass in one layer cabin. The energy superposition and diffusion caused by the charge position have a great influence on the damage effect of multi layer cabins. The better explosion position of the group charge is the middle cabin, and the better explosion position of two charges is the adjacent cabins or compartment in the middle, and the damage effect of one compartment is the best.