The composite photocatalysts were made by solid dispersion method with hydrophobic Zeolite and nanometer titanium dioxide.The removal of oxytetracycline (OTC) in water by UV/ Hydrophobic Zeolite loaded with different ratio of TiO2 was investigated respectively under the irradiation of 32 W lowpressure mercury lamps.The effects of composite photocatalyst quantity,initial OTC concentration and pH were studied.Results show that UV/composite photocatalyst with 40% TiO2 and 60% hydrophobic Zeolite is the best way to remove OTC in water compared to the others.99% of OTC (50 mg·L-1) in ultrapure water mixed with 500 mg·L-1 composite photocatalyst degrades within 150 min under UV irradiation.And after 6 hours,86% TOC of the OTC solution is removed.It is found that the degradation rate is quicker when the OTC initial concentration is lower and initial pH is higher.