关键词: 烟碱, 心血管, 氯异吲哚铵, 四甲双环庚戊安

Abstract: The experiment proved that elevation of blood pressure and cardio acceleration from nicotine can be blocked by the two drugs on the rat. Elevation of blood pressure from nicotine can be blocked by large dose of chlorisondamine (10 mg/kg) . Mecamylamine can only block cardio acceleration from nicotine on the rat, but long-term uses of mecamylamine do not block the effects of nicotine to cardiovascular system. The block function of effects from nicotine to cardiovascular system of chlorisondamine better than that of mecamylamine. The block function of large dose of chlorisondamine to ganglions can change the heart rate and blood pressure, and the heart rate and blood pressure changes controlled by block level of different dose of chlorisondamine and mecamylamine.

Key words: Nicotine, Cardiovascular, Chlorisondamine, Mecamylamine