Due to the poor knowledge of the influence law of the temperature profile of gas reservoirs, it is still highly challenging to quantitatively analyze the production profile of gas reservoirs using distributed optical fiber temperature monitoring (DTS). This is why the influence of multiple single factors on the directly determined well temperature profile of multi pay gas reservoir is simulated and analyzed by creating a prediction model for the directly determined well temperature profile of multi pay gas reservoir taking into account various micro thermal effects and non isothermal seepage. Through orthogonal test analysis, it is determined that each of the following factors has the following levels of influence on the straight well"s temperature profile in the gas reservoir with various production layers: permeability> production > water saturation > wellbore inclination angle > natural gas relative density > thermal conductivity of the reservoir > wellbore radius(k >Qg > SW > θ > dg > Kt > D), it is found that permeability, production, and water saturation are the main variables influencing the temperature profile of a straight well in a gas reservoir with various pay zones. A theoretical framework for the quantitative interpretation of the vertical well production profile of the gas reservoir based on DTS has been established by the development of the temperature profile prediction model and the identification of the primary temperature profile controls in this paper.