Computer simulation of mine evacuation can provide guidance for making emergency evacuation plans and verify the rationality of the plans in case of mine accidents or disasters. At present, the present studies seldom take account of individual cognitive differences and path selection differences that should be given weighted treatments. In this paper, a coal mine evacuation model is developed based on Multi-Agent and Dijkstra algorithm using RepastJ3.0 Java development platform, and the effects of the roadway topology knowledge level of the miner agents and the roadway variety on safety evacuation is discussed with the proposed model. The results indicate that safety evacuation varies with the roadway topology knowledge level of the miner agents and road weighted settings. The proposed model can directly and dynamically present the simulation process, which could be useful to provide theoretical supports for making emergency evacuation plans.